On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles

Jae Hyun Lee, Kuan Ju Chen, Seung Hyun Noh, Mitch André Garcia, Hao Wang, Wei Yu Lin, Heeyeong Jeong, Brian Junoh Kong, David B. Stout, Jinwoo Cheon, Hsian Rong Tseng

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142 Citations (Scopus)

Abstract

On-demand drug release: Magnetothermally responsive drug-encapsulated supramolecular nanoparticles for on-demand drug release in vivo have been developed. The remote application of an alternative magnetic field heats the magnetic particles that effectively trigger the release of the drug. An acute drug concentration can be delivered to the tumor in vivo, resulting in an improved therapeutic outcome.

Original languageEnglish
Pages (from-to)4384-4388
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number16
DOIs
Publication statusPublished - 2013 Apr 15

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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    Lee, J. H., Chen, K. J., Noh, S. H., Garcia, M. A., Wang, H., Lin, W. Y., Jeong, H., Kong, B. J., Stout, D. B., Cheon, J., & Tseng, H. R. (2013). On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. Angewandte Chemie - International Edition, 52(16), 4384-4388. https://doi.org/10.1002/anie.201207721