On the origin of leprosy

Marc Monot, Nadine Honoré, Thierry Garnier, Romulo Araoz, Jean Yves Coppée, Céline Lacroix, Samba Sow, John S. Spencer, Richard W. Truman, Diana L. Williams, Robert Gelber, Marcos Virmond, Béatrice Flageul, Sang Nae Cho, Baohong Ji, Alberto Paniz-Mondolfi, Jacinto Convit, Saroj Young, Paul E. Fine, Voahangy RasolofoPatrick J. Brennan, Stewart T. Cole

Research output: Contribution to journalArticle

292 Citations (Scopus)

Abstract

Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

Original languageEnglish
Pages (from-to)1040-1042
Number of pages3
JournalScience
Volume308
Issue number5724
DOIs
Publication statusPublished - 2005 May 13

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Leprosy
Human Migration
Mycobacterium leprae
Eastern Africa
Pseudogenes
Western Africa
Middle East
Genomics
Single Nucleotide Polymorphism
Chronic Disease
Clone Cells
Genome
Infection

All Science Journal Classification (ASJC) codes

  • General

Cite this

Monot, M., Honoré, N., Garnier, T., Araoz, R., Coppée, J. Y., Lacroix, C., ... Cole, S. T. (2005). On the origin of leprosy. Science, 308(5724), 1040-1042. https://doi.org/10.1126/science/1109759
Monot, Marc ; Honoré, Nadine ; Garnier, Thierry ; Araoz, Romulo ; Coppée, Jean Yves ; Lacroix, Céline ; Sow, Samba ; Spencer, John S. ; Truman, Richard W. ; Williams, Diana L. ; Gelber, Robert ; Virmond, Marcos ; Flageul, Béatrice ; Cho, Sang Nae ; Ji, Baohong ; Paniz-Mondolfi, Alberto ; Convit, Jacinto ; Young, Saroj ; Fine, Paul E. ; Rasolofo, Voahangy ; Brennan, Patrick J. ; Cole, Stewart T. / On the origin of leprosy. In: Science. 2005 ; Vol. 308, No. 5724. pp. 1040-1042.
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Monot, M, Honoré, N, Garnier, T, Araoz, R, Coppée, JY, Lacroix, C, Sow, S, Spencer, JS, Truman, RW, Williams, DL, Gelber, R, Virmond, M, Flageul, B, Cho, SN, Ji, B, Paniz-Mondolfi, A, Convit, J, Young, S, Fine, PE, Rasolofo, V, Brennan, PJ & Cole, ST 2005, 'On the origin of leprosy', Science, vol. 308, no. 5724, pp. 1040-1042. https://doi.org/10.1126/science/1109759

On the origin of leprosy. / Monot, Marc; Honoré, Nadine; Garnier, Thierry; Araoz, Romulo; Coppée, Jean Yves; Lacroix, Céline; Sow, Samba; Spencer, John S.; Truman, Richard W.; Williams, Diana L.; Gelber, Robert; Virmond, Marcos; Flageul, Béatrice; Cho, Sang Nae; Ji, Baohong; Paniz-Mondolfi, Alberto; Convit, Jacinto; Young, Saroj; Fine, Paul E.; Rasolofo, Voahangy; Brennan, Patrick J.; Cole, Stewart T.

In: Science, Vol. 308, No. 5724, 13.05.2005, p. 1040-1042.

Research output: Contribution to journalArticle

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AU - Monot, Marc

AU - Honoré, Nadine

AU - Garnier, Thierry

AU - Araoz, Romulo

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AU - Sow, Samba

AU - Spencer, John S.

AU - Truman, Richard W.

AU - Williams, Diana L.

AU - Gelber, Robert

AU - Virmond, Marcos

AU - Flageul, Béatrice

AU - Cho, Sang Nae

AU - Ji, Baohong

AU - Paniz-Mondolfi, Alberto

AU - Convit, Jacinto

AU - Young, Saroj

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AU - Brennan, Patrick J.

AU - Cole, Stewart T.

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Monot M, Honoré N, Garnier T, Araoz R, Coppée JY, Lacroix C et al. On the origin of leprosy. Science. 2005 May 13;308(5724):1040-1042. https://doi.org/10.1126/science/1109759