Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma

Won Sik Shin, Junhye Kwon, Hae Won Lee, Moon Chul Kang, Hye Won Na, Seung Taek Lee, Jong Ho Park

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer that is particularly prevalent in East Asian countries. Our previous expression profile analysis showed that the gene encoding protein tyrosine kinase 7 (PTK7) is upregulated in ESCC tissues. Here, we aimed to validate PTK7 as a prognostic factor and a candidate target for molecular treatment of ESCC. Both RT-PCR and Western blot analysis of tissues from ESCC patients revealed that PTK7 was significantly upregulated in tumor tissue samples of ESCC. Immunohistochemical staining of PTK7 showed that increased expression of PTK7 was inversely correlated with overall survival (P = 0.021). In vitro knockdown of PTK7 inhibited proliferation, survival, wound healing, and invasion of ESCC cells. In addition, PTK7 knockdown decreased phosphorylation of Akt, Erk, and focal adhesion kinase (FAK), important determinants of cell proliferation, survival, and migration. Therefore, our findings suggest that PTK7 has potential as a prognostic marker for ESCC and might also be a candidate for targeted therapy in the treatment of ESCC.

Original languageEnglish
Pages (from-to)1120-1126
Number of pages7
JournalCancer Science
Volume104
Issue number8
DOIs
Publication statusPublished - 2013 Aug

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Shin, W. S., Kwon, J., Lee, H. W., Kang, M. C., Na, H. W., Lee, S. T., & Park, J. H. (2013). Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma. Cancer Science, 104(8), 1120-1126. https://doi.org/10.1111/cas.12194