One-pot synthesis of conjugated alkynenitriles from aldehydes

Joong Gon Kim, Eun Hwa Lee, Doo Ok Jang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A method of preparing conjugated alkynenitriles was developed from various aldehydes with CCl3CN and PPh3 in the presence of tBuLi. The reaction proceeded via α-chlorovinyl nitrile as an intermediate without any side reactions such as chlorination of starting aldehydes.

Original languageEnglish
Pages (from-to)2299-2301
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number13
DOIs
Publication statusPublished - 2007 Mar 26

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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