A method of preparing conjugated alkynenitriles was developed from various aldehydes with CCl3CN and PPh3 in the presence of tBuLi. The reaction proceeded via α-chlorovinyl nitrile as an intermediate without any side reactions such as chlorination of starting aldehydes.
Bibliographical noteFunding Information:
This work was supported by Center for Bioactive Molecular Hybrids at Yonsei University.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry