One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions

Ji Hye Kim, Doo Ok Jang

Research output: Contribution to journalArticle

Abstract

A one-pot procedure for the synthesis of hydrazine derivatives from aldehydes via radical addition reactions was developed. Lewis acids promoted both the condensation between aldehydes and benzhydrazide, and the alkyl radical addition to the Cdbnd N bond of hydrazones, affording moderate-to-high yields of hydrazine derivatives. The present process provides a tin-free radical, sustainable, and eco-friendly synthetic method.

Original languageEnglish
Pages (from-to)2763-2766
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number28
DOIs
Publication statusPublished - 2018 Jul 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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