A one-pot procedure for the synthesis of hydrazine derivatives from aldehydes via radical addition reactions was developed. Lewis acids promoted both the condensation between aldehydes and benzhydrazide, and the alkyl radical addition to the Cdbnd N bond of hydrazones, affording moderate-to-high yields of hydrazine derivatives. The present process provides a tin-free radical, sustainable, and eco-friendly synthetic method.
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© 2018 Elsevier Ltd
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry