One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions

Ji Hye Kim; Doo Ok Jang

doi:10.1016/j.tetlet.2018.06.007

One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions

Ji Hye Kim, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A one-pot procedure for the synthesis of hydrazine derivatives from aldehydes via radical addition reactions was developed. Lewis acids promoted both the condensation between aldehydes and benzhydrazide, and the alkyl radical addition to the Cdbnd N bond of hydrazones, affording moderate-to-high yields of hydrazine derivatives. The present process provides a tin-free radical, sustainable, and eco-friendly synthetic method.

Original language	English
Pages (from-to)	2763-2766
Number of pages	4
Journal	Tetrahedron Letters
Volume	59
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2018.06.007
Publication status	Published - 2018 Jul 11

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Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2018.06.007

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abstract = "A one-pot procedure for the synthesis of hydrazine derivatives from aldehydes via radical addition reactions was developed. Lewis acids promoted both the condensation between aldehydes and benzhydrazide, and the alkyl radical addition to the Cdbnd N bond of hydrazones, affording moderate-to-high yields of hydrazine derivatives. The present process provides a tin-free radical, sustainable, and eco-friendly synthetic method.",

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AB - A one-pot procedure for the synthesis of hydrazine derivatives from aldehydes via radical addition reactions was developed. Lewis acids promoted both the condensation between aldehydes and benzhydrazide, and the alkyl radical addition to the Cdbnd N bond of hydrazones, affording moderate-to-high yields of hydrazine derivatives. The present process provides a tin-free radical, sustainable, and eco-friendly synthetic method.

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One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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