One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Astha Kukreja, Eun Kyung Lim, Byunghoon Kang, Yuna Choi, Taeksu Lee, Jin Ssuck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.

Original languageEnglish
Pages (from-to)2489-2498
Number of pages10
JournalInternational journal of nanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 May 21

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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