One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Astha Kukreja, Eun Kyung Lim, Byunghoon Kang, Yuna Choi, Taeksu Lee, Jin Ssuck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.

Original languageEnglish
Pages (from-to)2489-2498
Number of pages10
JournalInternational journal of nanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 May 21

Fingerprint

Dextran
Nanoclusters
Magnetic resonance
Dextrans
Atherosclerosis
Magnetic Resonance Imaging
Imaging techniques
Contrast Media
Dromaiidae
Macrophages
Biocompatibility
Surface-Active Agents
Magnetization
Surface active agents
Electrons
Water

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

Cite this

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abstract = "In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.",
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One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging. / Kukreja, Astha; Lim, Eun Kyung; Kang, Byunghoon; Choi, Yuna; Lee, Taeksu; Suh, Jin Ssuck; Huh, Yong Min; Haam, Seungjoo.

In: International journal of nanomedicine, Vol. 9, No. 1, 21.05.2014, p. 2489-2498.

Research output: Contribution to journalArticle

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AU - Kukreja, Astha

AU - Lim, Eun Kyung

AU - Kang, Byunghoon

AU - Choi, Yuna

AU - Lee, Taeksu

AU - Suh, Jin Ssuck

AU - Huh, Yong Min

AU - Haam, Seungjoo

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