A series of tricyclic dihydropyrimidine derivatives were synthesized using a one-pot, three-component Traube-Schwarz reaction in the presence of catalyst Zn(ClO4)2·6H2O. All the purified compounds were evaluated for their in vitro anticancer activity against three different cancer cell lines such as prostate cancer cells (PC3), lung cancer cells (NCI-H1299) and colon cancer cells (HCT116). In vitro DNA-intercalation ability of the compounds was investigated by UV-vis absorption spectroscopy, showing the insertion of compound into the DNA base pairs and a strong interaction with the DNA double helix.
Bibliographical noteFunding Information:
This work was supported by the India-Korea Joint Program of Cooperation in Science & Technology ( 2011-0027710 ) and the CSIR (Project No: 01(2417)/10/EMR-II ) project. T. Aree is thankful for partial financial support from the Ratchadapisek Sompoch Endowment Fund, Chulalongkorn University ( CU-56-007-FC ) and the National Research University Project of Thailand ( WCU-016-FW-57 ).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry