One-pot synthesis of tricyclic dihydropyrimidine derivatives and their biological evaluation

Navneet Kaur, Kamalpreet Kaur, Tilak Raj, Gaganpreet Kaur, Ajnesh Singh, Thammarat Aree, Sae Jin Park, Tack Joong Kim, Narinder Singh, Doo Ok Jang

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Abstract

A series of tricyclic dihydropyrimidine derivatives were synthesized using a one-pot, three-component Traube-Schwarz reaction in the presence of catalyst Zn(ClO4)2·6H2O. All the purified compounds were evaluated for their in vitro anticancer activity against three different cancer cell lines such as prostate cancer cells (PC3), lung cancer cells (NCI-H1299) and colon cancer cells (HCT116). In vitro DNA-intercalation ability of the compounds was investigated by UV-vis absorption spectroscopy, showing the insertion of compound into the DNA base pairs and a strong interaction with the DNA double helix.

Original languageEnglish
Pages (from-to)332-337
Number of pages6
JournalTetrahedron
Volume71
Issue number2
DOIs
Publication statusPublished - 2015 Jan 14

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Kaur, N., Kaur, K., Raj, T., Kaur, G., Singh, A., Aree, T., Park, S. J., Kim, T. J., Singh, N., & Jang, D. O. (2015). One-pot synthesis of tricyclic dihydropyrimidine derivatives and their biological evaluation. Tetrahedron, 71(2), 332-337. https://doi.org/10.1016/j.tet.2014.11.039