Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF 3 -OEt 2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.
Bibliographical noteFunding Information:
We thank the National Research Foundation of Korea (NRF-2017R1A2A2A05069364 and NRF-2018R1A6A1A03023718) for generous financial support.
All Science Journal Classification (ASJC) codes
- Organic Chemistry