One-step microfluidic chip for circulating tumor cell enrichment

K. A. Hyun, T. Y. Lee, S. I. Kim, H. I. Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Circulating tumor cells (CTCs) play a large role in metastatic process because few of them are transported to potential metastatic sites after shedding them into the vasculature. However, CTCs are rare in the peripheral blood of cancer patients (1-100 CTCs per 109 blood cells) and even these cells have heterogeneous feature[1]. In this paper, we introduce an integrated microfluidic chip, termed the μ-MixMACS chip, that can negatively exclude background cells from a CTC population by one-step from tagging the non-target cell with magnetic nanoparticles (MNPs) to elimination of MNPs covered cells.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages2068-2069
Number of pages2
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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