One-year clinical outcomes of everolimus-versus sirolimus-eluting stents in patients with acute myocardial infarction

Kang Yin Chen, Seung Woon Rha, Lin Wang, Yong Jian Li, Guang Ping Li, Cheol Ung Choi, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong, Young Keun Ahn, Taek Jong Hong, Young Jo Kim, Shung Chull Chae, Seung Ho Hur, In Whan Seong, Jei Keon Chae, Myeong Chan Cho, Jang Ho Bae, Dong Hoon ChoiYang Soo Jang, In Ho Chae, Hyo Soo Kim, Chong Jin Kim, Jung Han Yoon, Tae Hoon Ahn, Wook Sung Chung, Ki Bae Seung, Seung Jung Park

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Abstract

Background: In contrast to many studies comparing everolimus-eluting stent (EES) with paclitaxel-eluting stent (PES), data directly comparing EES with sirolimus-eluting stent (SES) are limited, especially in patients with acute myocardial infarction (AMI).

Methods: This study includes 2911 AMI patients treated with SES (n= 1264) or EES (n= 1701) in Korea Acute Myocardial Infarction Registry (KAMIR). Propensity scorematching was applied to adjust for baseline imbalance in clinical and angiographic characteristics, yielding a total of 2400 well-matched patients (1200 receiving SES and 1200 receiving EES). One-year clinical outcomeswere compared between the two propensity scorematched groups.

Results: Baseline clinical and angiographic characteristics were similar between the two propensity score matched groups. One-year clinical outcomes of the propensity score matched cohort were comparable between the EES versus the SES groups including the rates of cardiac death (4.8% vs. 4.8%, P= 1.000), recurrent myocardial infarction (1.4% vs. 1.7%, P= 0.619), target lesion revascularization (1.4% vs. 1.6%, P= 0.737), target lesion failure (7.0% vs. 7.3%, P= 0.752), and probable or definite stent thrombosis (0.5% vs. 0.9%, P= 0.224) except for a trend toward lower incidence of target vessel revascularization (1.9% vs. 3.0%, P= 0.087) and a lower rate of total major adverse cardiac events (9.3% vs. 11.9%, P = 0.034) in the EES group.

Conclusions: The present propensity scorematched analysis performed in a large-scale, prospective, multicenter registry suggests that the second-generation drug-eluting stent EES has at least comparable or even better safety and efficacy profiles as compared with SES in the setting of AMI.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalInternational Journal of Cardiology
Volume176
Issue number3
DOIs
Publication statusPublished - 2014 Oct 20

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Chen, K. Y., Rha, S. W., Wang, L., Li, Y. J., Li, G. P., Choi, C. U., Park, C. G., Seo, H. S., Oh, D. J., Jeong, M. H., Ahn, Y. K., Hong, T. J., Kim, Y. J., Chae, S. C., Hur, S. H., Seong, I. W., Chae, J. K., Cho, M. C., Bae, J. H., ... Park, S. J. (2014). One-year clinical outcomes of everolimus-versus sirolimus-eluting stents in patients with acute myocardial infarction. International Journal of Cardiology, 176(3), 583-588. https://doi.org/10.1016/j.ijcard.2014.08.049