Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang, Jong Eun Lee, Kwan Ho Lee, Jae Wan Huh, Soo Young Choi, Sung Woo Cho

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Abstract

When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalMolecular Brain Research
Volume127
Issue number1-2
DOIs
Publication statusPublished - 2004 Aug 23

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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