Abstract
When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
| Original language | English |
|---|---|
| Pages (from-to) | 146-149 |
| Number of pages | 4 |
| Journal | Molecular Brain Research |
| Volume | 127 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2004 Aug 23 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience
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Cite this
Yang, S. J., Lee, J. E., Lee, K. H., Huh, J. W., Choi, S. Y., & Cho, S. W. (2004). Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. Molecular Brain Research, 127(1-2), 146-149. https://doi.org/10.1016/j.molbrainres.2004.05.016