When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
Bibliographical noteFunding Information:
This work was supported by grants from the Korea Health R&D Project from The Ministry of Health and Welfare (02-PJ1-PG10-21304-0007) and University of Ulsan Asan Institute for Life Sciences (2004-080).
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience