Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang; Jong Eun Lee; Kwan Ho Lee; Jae Wan Huh; Soo Young Choi; Sung Woo Cho

doi:10.1016/j.molbrainres.2004.05.016

Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang, Jong Eun Lee, Kwan Ho Lee, Jae Wan Huh, Soo Young Choi, Sung Woo Cho

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

Original language	English
Pages (from-to)	146-149
Number of pages	4
Journal	Molecular Brain Research
Volume	127
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molbrainres.2004.05.016
Publication status	Published - 2004 Aug 23

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Health R&D Project from The Ministry of Health and Welfare (02-PJ1-PG10-21304-0007) and University of Ulsan Asan Institute for Life Sciences (2004-080).

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/j.molbrainres.2004.05.016

Cite this

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title = "Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains",

abstract = "When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.",

author = "Yang, {Seung Ju} and Lee, {Jong Eun} and Lee, {Kwan Ho} and Huh, {Jae Wan} and Choi, {Soo Young} and Cho, {Sung Woo}",

note = "Funding Information: This work was supported by grants from the Korea Health R&D Project from The Ministry of Health and Welfare (02-PJ1-PG10-21304-0007) and University of Ulsan Asan Institute for Life Sciences (2004-080).",

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T1 - Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

AU - Yang, Seung Ju

AU - Lee, Jong Eun

AU - Lee, Kwan Ho

AU - Huh, Jae Wan

AU - Choi, Soo Young

AU - Cho, Sung Woo

N1 - Funding Information: This work was supported by grants from the Korea Health R&D Project from The Ministry of Health and Welfare (02-PJ1-PG10-21304-0007) and University of Ulsan Asan Institute for Life Sciences (2004-080).

PY - 2004/8/23

Y1 - 2004/8/23

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AB - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

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Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Abstract

Bibliographical note

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