Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang, Jongeun Lee, Kwan Ho Lee, Jae Wan Huh, Soo Young Choi, Sung Woo Cho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalMolecular Brain Research
Volume127
Issue number1-2
DOIs
Publication statusPublished - 2004 Aug 23

Fingerprint

Glial Cell Line-Derived Neurotrophic Factor
Brain-Derived Neurotrophic Factor
Aluminum
Apoptosis
Brain
Caspase 12
Nerve Growth Factors
DNA Fragmentation
Caspase 3
Cell Death

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Yang, Seung Ju ; Lee, Jongeun ; Lee, Kwan Ho ; Huh, Jae Wan ; Choi, Soo Young ; Cho, Sung Woo. / Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. In: Molecular Brain Research. 2004 ; Vol. 127, No. 1-2. pp. 146-149.
@article{a0ba80b1c8d2419ab832efccee35e449,
title = "Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains",
abstract = "When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.",
author = "Yang, {Seung Ju} and Jongeun Lee and Lee, {Kwan Ho} and Huh, {Jae Wan} and Choi, {Soo Young} and Cho, {Sung Woo}",
year = "2004",
month = "8",
day = "23",
doi = "10.1016/j.molbrainres.2004.05.016",
language = "English",
volume = "127",
pages = "146--149",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. / Yang, Seung Ju; Lee, Jongeun; Lee, Kwan Ho; Huh, Jae Wan; Choi, Soo Young; Cho, Sung Woo.

In: Molecular Brain Research, Vol. 127, No. 1-2, 23.08.2004, p. 146-149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

AU - Yang, Seung Ju

AU - Lee, Jongeun

AU - Lee, Kwan Ho

AU - Huh, Jae Wan

AU - Choi, Soo Young

AU - Cho, Sung Woo

PY - 2004/8/23

Y1 - 2004/8/23

N2 - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

AB - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

UR - http://www.scopus.com/inward/record.url?scp=4043048649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043048649&partnerID=8YFLogxK

U2 - 10.1016/j.molbrainres.2004.05.016

DO - 10.1016/j.molbrainres.2004.05.016

M3 - Article

C2 - 15306132

AN - SCOPUS:4043048649

VL - 127

SP - 146

EP - 149

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -