Abstract
When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
Original language | English |
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Pages (from-to) | 146-149 |
Number of pages | 4 |
Journal | Molecular Brain Research |
Volume | 127 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2004 Aug 23 |
Bibliographical note
Funding Information:This work was supported by grants from the Korea Health R&D Project from The Ministry of Health and Welfare (02-PJ1-PG10-21304-0007) and University of Ulsan Asan Institute for Life Sciences (2004-080).
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience