Abstract
When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
| Original language | English |
|---|---|
| Pages (from-to) | 146-149 |
| Number of pages | 4 |
| Journal | Molecular Brain Research |
| Volume | 127 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2004 Aug 23 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience
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Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. / Yang, Seung Ju; Lee, Jong Eun; Lee, Kwan Ho; Huh, Jae Wan; Choi, Soo Young; Cho, Sung Woo.
In: Molecular Brain Research, Vol. 127, No. 1-2, 23.08.2004, p. 146-149.Research output: Contribution to journal › Article
TY - JOUR
T1 - Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains
AU - Yang, Seung Ju
AU - Lee, Jong Eun
AU - Lee, Kwan Ho
AU - Huh, Jae Wan
AU - Choi, Soo Young
AU - Cho, Sung Woo
PY - 2004/8/23
Y1 - 2004/8/23
N2 - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
AB - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.
UR - http://www.scopus.com/inward/record.url?scp=4043048649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4043048649&partnerID=8YFLogxK
U2 - 10.1016/j.molbrainres.2004.05.016
DO - 10.1016/j.molbrainres.2004.05.016
M3 - Article
C2 - 15306132
AN - SCOPUS:4043048649
VL - 127
SP - 146
EP - 149
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -