Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang; Jong Eun Lee; Kwan Ho Lee; Jae Wan Huh; Soo Young Choi; Sung Woo Cho

doi:10.1016/j.molbrainres.2004.05.016

Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

Seung Ju Yang, Jong Eun Lee, Kwan Ho Lee, Jae Wan Huh, Soo Young Choi, Sung Woo Cho

Department of Anatomy

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

Original language	English
Pages (from-to)	146-149
Number of pages	4
Journal	Molecular Brain Research
Volume	127
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molbrainres.2004.05.016
Publication status	Published - 2004 Aug 23

Fingerprint

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

Cite this

Yang, S. J., Lee, J. E., Lee, K. H., Huh, J. W., Choi, S. Y., & Cho, S. W. (2004). Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. Molecular Brain Research, 127(1-2), 146-149. https://doi.org/10.1016/j.molbrainres.2004.05.016

@article{a0ba80b1c8d2419ab832efccee35e449,

title = "Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains",

abstract = "When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.",

author = "Yang, {Seung Ju} and Lee, {Jong Eun} and Lee, {Kwan Ho} and Huh, {Jae Wan} and Choi, {Soo Young} and Cho, {Sung Woo}",

year = "2004",

month = aug

day = "23",

doi = "10.1016/j.molbrainres.2004.05.016",

language = "English",

volume = "127",

pages = "146--149",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains

AU - Yang, Seung Ju

AU - Lee, Jong Eun

AU - Lee, Kwan Ho

AU - Huh, Jae Wan

AU - Choi, Soo Young

AU - Cho, Sung Woo

PY - 2004/8/23

Y1 - 2004/8/23

N2 - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

AB - When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

UR - http://www.scopus.com/inward/record.url?scp=4043048649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043048649&partnerID=8YFLogxK

U2 - 10.1016/j.molbrainres.2004.05.016

DO - 10.1016/j.molbrainres.2004.05.016

M3 - Article

C2 - 15306132

AN - SCOPUS:4043048649

VL - 127

SP - 146

EP - 149

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

Access to Document

10.1016/j.molbrainres.2004.05.016