Optical coherence evaluation of everolimus-eluting stents 8 months after implantation

Takumi Inoue, Junya Shite, Junghan Yoon, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Katoh, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken Ichi Hirata

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Abstract

Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4%), and 31 (0.52%) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62%). Eleven EES (37%) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.

Original languageEnglish
Pages (from-to)1379-1384
Number of pages6
JournalHeart
Volume97
Issue number17
DOIs
Publication statusPublished - 2011 Sep 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Inoue, T., Shite, J., Yoon, J., Shinke, T., Otake, H., Sawada, T., Kawamori, H., Katoh, H., Miyoshi, N., Yoshino, N., Kozuki, A., Hariki, H., & Hirata, K. I. (2011). Optical coherence evaluation of everolimus-eluting stents 8 months after implantation. Heart, 97(17), 1379-1384. https://doi.org/10.1136/hrt.2010.204339