Optical coherence evaluation of everolimus-eluting stents 8 months after implantation

Takumi Inoue, Junya Shite, Junghan Yoon, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Katoh, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken Ichi Hirata

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4%), and 31 (0.52%) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62%). Eleven EES (37%) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.

Original languageEnglish
Pages (from-to)1379-1384
Number of pages6
JournalHeart
Volume97
Issue number17
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Stents
Neointima
Optical Coherence Tomography
Thrombosis
Everolimus
Coronary Vessels
Outcome Assessment (Health Care)
Clinical Trials
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Inoue, T., Shite, J., Yoon, J., Shinke, T., Otake, H., Sawada, T., ... Hirata, K. I. (2011). Optical coherence evaluation of everolimus-eluting stents 8 months after implantation. Heart, 97(17), 1379-1384. https://doi.org/10.1136/hrt.2010.204339
Inoue, Takumi ; Shite, Junya ; Yoon, Junghan ; Shinke, Toshiro ; Otake, Hiromasa ; Sawada, Takahiro ; Kawamori, Hiroyuki ; Katoh, Hiroki ; Miyoshi, Naoki ; Yoshino, Naoki ; Kozuki, Amane ; Hariki, Hirotoshi ; Hirata, Ken Ichi. / Optical coherence evaluation of everolimus-eluting stents 8 months after implantation. In: Heart. 2011 ; Vol. 97, No. 17. pp. 1379-1384.
@article{0c5fa0bdfca34a3b9f2235e980f52fd9,
title = "Optical coherence evaluation of everolimus-eluting stents 8 months after implantation",
abstract = "Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4{\%}), and 31 (0.52{\%}) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62{\%}). Eleven EES (37{\%}) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.",
author = "Takumi Inoue and Junya Shite and Junghan Yoon and Toshiro Shinke and Hiromasa Otake and Takahiro Sawada and Hiroyuki Kawamori and Hiroki Katoh and Naoki Miyoshi and Naoki Yoshino and Amane Kozuki and Hirotoshi Hariki and Hirata, {Ken Ichi}",
year = "2011",
month = "9",
day = "1",
doi = "10.1136/hrt.2010.204339",
language = "English",
volume = "97",
pages = "1379--1384",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "17",

}

Inoue, T, Shite, J, Yoon, J, Shinke, T, Otake, H, Sawada, T, Kawamori, H, Katoh, H, Miyoshi, N, Yoshino, N, Kozuki, A, Hariki, H & Hirata, KI 2011, 'Optical coherence evaluation of everolimus-eluting stents 8 months after implantation', Heart, vol. 97, no. 17, pp. 1379-1384. https://doi.org/10.1136/hrt.2010.204339

Optical coherence evaluation of everolimus-eluting stents 8 months after implantation. / Inoue, Takumi; Shite, Junya; Yoon, Junghan; Shinke, Toshiro; Otake, Hiromasa; Sawada, Takahiro; Kawamori, Hiroyuki; Katoh, Hiroki; Miyoshi, Naoki; Yoshino, Naoki; Kozuki, Amane; Hariki, Hirotoshi; Hirata, Ken Ichi.

In: Heart, Vol. 97, No. 17, 01.09.2011, p. 1379-1384.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Optical coherence evaluation of everolimus-eluting stents 8 months after implantation

AU - Inoue, Takumi

AU - Shite, Junya

AU - Yoon, Junghan

AU - Shinke, Toshiro

AU - Otake, Hiromasa

AU - Sawada, Takahiro

AU - Kawamori, Hiroyuki

AU - Katoh, Hiroki

AU - Miyoshi, Naoki

AU - Yoshino, Naoki

AU - Kozuki, Amane

AU - Hariki, Hirotoshi

AU - Hirata, Ken Ichi

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4%), and 31 (0.52%) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62%). Eleven EES (37%) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.

AB - Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4%), and 31 (0.52%) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62%). Eleven EES (37%) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=80051552401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051552401&partnerID=8YFLogxK

U2 - 10.1136/hrt.2010.204339

DO - 10.1136/hrt.2010.204339

M3 - Article

C2 - 21051456

AN - SCOPUS:80051552401

VL - 97

SP - 1379

EP - 1384

JO - Heart

JF - Heart

SN - 1355-6037

IS - 17

ER -