Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

Youngjin Oh; Namkyeong Jeon; Jin Kim; Donghyun Kim

doi:10.1016/j.cap.2009.05.023

Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

Youngjin Oh, Namkyeong Jeon, Jin Kim, Donghyun Kim

Research output: Contribution to journal › Article › peer-review

Abstract

We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μ_t) calculated by collimated transmission method. Although direct comparison of μ_t may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μ_t shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.

Original language	English
Pages (from-to)	e206-e209
Journal	Current Applied Physics
Volume	9
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.cap.2009.05.023
Publication status	Published - 2009 Jul

Bibliographical note

Funding Information:
The authors thank the support by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0), and KOSEF 2007-8-1158. This work was partially sponsored by the KOSEF grant funded by No. R01-2007-000-20821-0 and also supported by “System IC 2010” project of Ministry of Knowledge Economy and the MEMS Research Center for National Defense funded by the Defense Acquisition Program Administration. This research was sponsored in part by the Korea Research Foundation Grant (MOEHRD, KRF-2005-005-J05901).

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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10.1016/j.cap.2009.05.023

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title = "Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants",

abstract = "We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μt) calculated by collimated transmission method. Although direct comparison of μt may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μt shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.",

author = "Youngjin Oh and Namkyeong Jeon and Jin Kim and Donghyun Kim",

note = "Funding Information: The authors thank the support by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0), and KOSEF 2007-8-1158. This work was partially sponsored by the KOSEF grant funded by No. R01-2007-000-20821-0 and also supported by “System IC 2010” project of Ministry of Knowledge Economy and the MEMS Research Center for National Defense funded by the Defense Acquisition Program Administration. This research was sponsored in part by the Korea Research Foundation Grant (MOEHRD, KRF-2005-005-J05901).",

year = "2009",

month = jul,

doi = "10.1016/j.cap.2009.05.023",

language = "English",

volume = "9",

pages = "e206--e209",

journal = "Current Applied Physics",

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AU - Jeon, Namkyeong

AU - Kim, Jin

AU - Kim, Donghyun

N1 - Funding Information: The authors thank the support by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0), and KOSEF 2007-8-1158. This work was partially sponsored by the KOSEF grant funded by No. R01-2007-000-20821-0 and also supported by “System IC 2010” project of Ministry of Knowledge Economy and the MEMS Research Center for National Defense funded by the Defense Acquisition Program Administration. This research was sponsored in part by the Korea Research Foundation Grant (MOEHRD, KRF-2005-005-J05901).

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N2 - We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μt) calculated by collimated transmission method. Although direct comparison of μt may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μt shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.

AB - We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μt) calculated by collimated transmission method. Although direct comparison of μt may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μt shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.

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SN - 1567-1739

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Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

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Bibliographical note

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