Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

Youngjin Oh; Namkyeong Jeon; Jin Kim; Donghyun Kim

doi:10.1016/j.cap.2009.05.023

Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

Youngjin Oh, Namkyeong Jeon, Jin Kim, Donghyun Kim

Research output: Contribution to journal › Article

Abstract

We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μ_t) calculated by collimated transmission method. Although direct comparison of μ_t may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μ_t shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.

Original language	English
Pages (from-to)	e206-e209
Journal	Current Applied Physics
Volume	9
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.cap.2009.05.023
Publication status	Published - 2009 Jul 1

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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Oh, Y., Jeon, N., Kim, J., & Kim, D. (2009). Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants. Current Applied Physics, 9(4 SUPPL.), e206-e209. https://doi.org/10.1016/j.cap.2009.05.023

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