We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450-750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μt) calculated by collimated transmission method. Although direct comparison of μt may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μt shows promise for the diagnosis. The preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.
Bibliographical noteFunding Information:
The authors thank the support by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0), and KOSEF 2007-8-1158. This work was partially sponsored by the KOSEF grant funded by No. R01-2007-000-20821-0 and also supported by “System IC 2010” project of Ministry of Knowledge Economy and the MEMS Research Center for National Defense funded by the Defense Acquisition Program Administration. This research was sponsored in part by the Korea Research Foundation Grant (MOEHRD, KRF-2005-005-J05901).
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)