Optical separation of cells on potential energy landscapes: Enhancement with dielectric tagging

Kishan Dholakia; Woei Ming Lee; Lynn Paterson; Michael P. MacDonald; Richard McDonald; Igor Andreev; Patience Mthunzi; C. Tom A. Brown; Robert F. Marchington; Andrew C. Riches

doi:10.1109/JSTQE.2007.911314

Optical separation of cells on potential energy landscapes: Enhancement with dielectric tagging

Kishan Dholakia, Woei Ming Lee, Lynn Paterson, Michael P. MacDonald, Richard McDonald, Igor Andreev, Patience Mthunzi, C. Tom A. Brown, Robert F. Marchington, Andrew C. Riches

Department of Physics

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We review the emergent techniques of microfluidic sorting of colloidal and cellular samples using optical forces. We distinguish between what we term as passive and active forms of particle sorting where we can sort either with the use of a fluorescent marker (active) or based on physical attributes alone (passive). We then examine cell sorting with optical potential landscapes such as a Bessel light beam and a multibeam interference pattern. For both forms of optical potential energy landscape, we further present the possibility of enhancing the optical sorting process by tagging dielectric microspheres onto the cells. The results suggest that the methodology of tagging can enhance the sorting of cells as they subsequently respond more strongly to an applied optical field or potential energy landscape. This technique presents a simple method to enhance the sorting process.

Original language	English
Pages (from-to)	1646-1654
Number of pages	9
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	13
Issue number	6
DOIs	https://doi.org/10.1109/JSTQE.2007.911314
Publication status	Published - 2007 Nov

Bibliographical note

Funding Information:
Manuscript received September 6, 2007; revised October 12, 2007. This work was supported by the European Science Foundation under Grant Novel Optical Methods For Self-Assembled Nanostructures (NOMSAN), which was supported by grants from the U.K. Engineering and Physical Sciences Research Council and the European Framework Six Programme.

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2007.911314

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Dholakia, K., Lee, W. M., Paterson, L., MacDonald, M. P., McDonald, R., Andreev, I., Mthunzi, P., Brown, C. T. A., Marchington, R. F., & Riches, A. C. (2007). Optical separation of cells on potential energy landscapes: Enhancement with dielectric tagging. IEEE Journal on Selected Topics in Quantum Electronics, 13(6), 1646-1654. https://doi.org/10.1109/JSTQE.2007.911314

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abstract = "We review the emergent techniques of microfluidic sorting of colloidal and cellular samples using optical forces. We distinguish between what we term as passive and active forms of particle sorting where we can sort either with the use of a fluorescent marker (active) or based on physical attributes alone (passive). We then examine cell sorting with optical potential landscapes such as a Bessel light beam and a multibeam interference pattern. For both forms of optical potential energy landscape, we further present the possibility of enhancing the optical sorting process by tagging dielectric microspheres onto the cells. The results suggest that the methodology of tagging can enhance the sorting of cells as they subsequently respond more strongly to an applied optical field or potential energy landscape. This technique presents a simple method to enhance the sorting process.",

author = "Kishan Dholakia and Lee, {Woei Ming} and Lynn Paterson and MacDonald, {Michael P.} and Richard McDonald and Igor Andreev and Patience Mthunzi and Brown, {C. Tom A.} and Marchington, {Robert F.} and Riches, {Andrew C.}",

note = "Funding Information: Manuscript received September 6, 2007; revised October 12, 2007. This work was supported by the European Science Foundation under Grant Novel Optical Methods For Self-Assembled Nanostructures (NOMSAN), which was supported by grants from the U.K. Engineering and Physical Sciences Research Council and the European Framework Six Programme.",

year = "2007",

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doi = "10.1109/JSTQE.2007.911314",

language = "English",

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AU - Dholakia, Kishan

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AU - Paterson, Lynn

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AU - McDonald, Richard

AU - Andreev, Igor

AU - Mthunzi, Patience

AU - Brown, C. Tom A.

AU - Marchington, Robert F.

AU - Riches, Andrew C.

N1 - Funding Information: Manuscript received September 6, 2007; revised October 12, 2007. This work was supported by the European Science Foundation under Grant Novel Optical Methods For Self-Assembled Nanostructures (NOMSAN), which was supported by grants from the U.K. Engineering and Physical Sciences Research Council and the European Framework Six Programme.

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N2 - We review the emergent techniques of microfluidic sorting of colloidal and cellular samples using optical forces. We distinguish between what we term as passive and active forms of particle sorting where we can sort either with the use of a fluorescent marker (active) or based on physical attributes alone (passive). We then examine cell sorting with optical potential landscapes such as a Bessel light beam and a multibeam interference pattern. For both forms of optical potential energy landscape, we further present the possibility of enhancing the optical sorting process by tagging dielectric microspheres onto the cells. The results suggest that the methodology of tagging can enhance the sorting of cells as they subsequently respond more strongly to an applied optical field or potential energy landscape. This technique presents a simple method to enhance the sorting process.

AB - We review the emergent techniques of microfluidic sorting of colloidal and cellular samples using optical forces. We distinguish between what we term as passive and active forms of particle sorting where we can sort either with the use of a fluorescent marker (active) or based on physical attributes alone (passive). We then examine cell sorting with optical potential landscapes such as a Bessel light beam and a multibeam interference pattern. For both forms of optical potential energy landscape, we further present the possibility of enhancing the optical sorting process by tagging dielectric microspheres onto the cells. The results suggest that the methodology of tagging can enhance the sorting of cells as they subsequently respond more strongly to an applied optical field or potential energy landscape. This technique presents a simple method to enhance the sorting process.

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Optical separation of cells on potential energy landscapes: Enhancement with dielectric tagging

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Bibliographical note

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