Optimal duration of DAPT after second-generation drug-eluting stent in acute coronary syndrome

Ji Yong Jang, Dong Ho Shin, Jung Sun Kim, Sung Jin Hong, Chul Min Ahn, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Myeong Ki Hong, Kyung Woo Park, Hyeon Cheol Gwon, Hyo Soo Kim, Yangsoo Jang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background We evaluated optimal duration of dual antiplatelet therapy (DAPT) after second-generation drug-eluting stent (DES) implantation in acute coronary syndrome (ACS). Material and methods From pooled analysis of three randomized clinical trials (EXCELLENT, IVUS-XPL, RESET), a total of 2,216 patient with ACS undergoing second-generation DES implantation were selected. Each study randomized patients to a short-duration DAPT arm (n = 1119; 6 months) or a standard-duration DAPT arm (n = 1097; 12 months). Two-thirds of patients were male, and their mean age was 63 years. Mean DAPT durations were 164 ±76 and 359 ±68 days, respectively. The primary endpoint was composite of cardiac death, myocardial infarction, stent thrombosis, stroke or major bleeding during the first 12 months after implantation, analyzed according to the intention-to-treat population. Results Demographic characteristics were balanced between groups. Mean DAPT duration was 164 and 359 days, respectively. Primary endpoint occurred in 22 patients with short-DAPT and 21 patients with standard-DAPT (2.0% versus 1.9%; hazard ratio [HR] 1.03; 95% confidence interval [CI] 0.56–1.86; p = 0.94). Landmark analysis after six-months, no significant difference in primary endpoint between short and standard duration DAPT (1.0% versus 0.8%; HR 1.22; 95% CI 0.51–2.95; p = 0.66). Conclusions Short-duration DAPT (6 months) demonstrated a similar incidence of net adverse cardiovascular and clinical events at 12 months after second-generation DES in ACS compared with standard duration DAPT (12 months).

Original languageEnglish
Article numbere0207386
JournalPloS one
Volume13
Issue number11
DOIs
Publication statusPublished - 2018 Nov

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Optimal duration of DAPT after second-generation drug-eluting stent in acute coronary syndrome'. Together they form a unique fingerprint.

  • Cite this

    Jang, J. Y., Shin, D. H., Kim, J. S., Hong, S. J., Ahn, C. M., Kim, B. K., Ko, Y. G., Choi, D., Hong, M. K., Park, K. W., Gwon, H. C., Kim, H. S., & Jang, Y. (2018). Optimal duration of DAPT after second-generation drug-eluting stent in acute coronary syndrome. PloS one, 13(11), [e0207386]. https://doi.org/10.1371/journal.pone.0207386