Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults: A retrospective study based on the oral glucose tolerance test

You Cheol Hwang, Chang Hee Jung, Hong Yup Ahn, Won Seon Jeon, Sang Man Jin, Jeong taek Woo, Bong Soo Cha, Jae Hyeon Kim, Cheol Young Park, Byung Wan Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-diabetes and diabetes in Korean adults. In addition, we compared the performance of GA for the diagnosis of diabetes with that of glycated hemoglobin (A1c). Materials and methods: A total of 852 subjects (498 males, 354 females) aged 20 to 83. years (mean: 52.5. years) were enrolled. A 75-g oral glucose tolerance test (OGTT) was performed and A1c and GA were measured. Results: In these enrolled subjects, 88% have glucose intolerance status (pre-diabetes or diabetes). The GA concentrations corresponding to fasting plasma glucose (FPG) of 7.0. mmol/l, 2-h plasma glucose during OGTT (PPG2). ≥. 11.1. mmol/l, and A1c. ≥. 6.5% were 14.6%, 13.7%, and 14.7%, respectively. A meta-analysis of three GA cutoffs revealed a GA cutoff for diabetes of 14.3%. When A1c is used in combination with FPG, the sensitivity and specificity for the diagnosis of OGTT-based diabetes were 72.16% (95% CI: 66.6-72.2) and 96.4% (95% CI: 94.4-97.7), respectively. With the newly developed GA cutoff of 14.3%, GA combined with FPG resulted in a sensitivity and specificity of 77.5% (95% CI: 72.17-82.0) and 89.9% (95% CI: 87.1-92.2), respectively. Conclusions: A GA cutoff of >. 14.3% is optimal for the diagnosis of diabetes in Korean adults. The measurement of FPG and GA may detect diabetes earlier than the measurement of FPG and A1c.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalClinica Chimica Acta
Volume437
DOIs
Publication statusPublished - 2014 Nov 1

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Glucose Tolerance Test
Medical problems
Retrospective Studies
Glucose
Fasting
Plasmas
glycosylated serum albumin
Sensitivity and Specificity
Glucose Intolerance
Glycosylated Hemoglobin A
Serum Albumin
Meta-Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Hwang, You Cheol ; Jung, Chang Hee ; Ahn, Hong Yup ; Jeon, Won Seon ; Jin, Sang Man ; Woo, Jeong taek ; Cha, Bong Soo ; Kim, Jae Hyeon ; Park, Cheol Young ; Lee, Byung Wan. / Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults : A retrospective study based on the oral glucose tolerance test. In: Clinica Chimica Acta. 2014 ; Vol. 437. pp. 1-5.
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title = "Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults: A retrospective study based on the oral glucose tolerance test",
abstract = "Introduction: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-diabetes and diabetes in Korean adults. In addition, we compared the performance of GA for the diagnosis of diabetes with that of glycated hemoglobin (A1c). Materials and methods: A total of 852 subjects (498 males, 354 females) aged 20 to 83. years (mean: 52.5. years) were enrolled. A 75-g oral glucose tolerance test (OGTT) was performed and A1c and GA were measured. Results: In these enrolled subjects, 88{\%} have glucose intolerance status (pre-diabetes or diabetes). The GA concentrations corresponding to fasting plasma glucose (FPG) of 7.0. mmol/l, 2-h plasma glucose during OGTT (PPG2). ≥. 11.1. mmol/l, and A1c. ≥. 6.5{\%} were 14.6{\%}, 13.7{\%}, and 14.7{\%}, respectively. A meta-analysis of three GA cutoffs revealed a GA cutoff for diabetes of 14.3{\%}. When A1c is used in combination with FPG, the sensitivity and specificity for the diagnosis of OGTT-based diabetes were 72.16{\%} (95{\%} CI: 66.6-72.2) and 96.4{\%} (95{\%} CI: 94.4-97.7), respectively. With the newly developed GA cutoff of 14.3{\%}, GA combined with FPG resulted in a sensitivity and specificity of 77.5{\%} (95{\%} CI: 72.17-82.0) and 89.9{\%} (95{\%} CI: 87.1-92.2), respectively. Conclusions: A GA cutoff of >. 14.3{\%} is optimal for the diagnosis of diabetes in Korean adults. The measurement of FPG and GA may detect diabetes earlier than the measurement of FPG and A1c.",
author = "Hwang, {You Cheol} and Jung, {Chang Hee} and Ahn, {Hong Yup} and Jeon, {Won Seon} and Jin, {Sang Man} and Woo, {Jeong taek} and Cha, {Bong Soo} and Kim, {Jae Hyeon} and Park, {Cheol Young} and Lee, {Byung Wan}",
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Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults : A retrospective study based on the oral glucose tolerance test. / Hwang, You Cheol; Jung, Chang Hee; Ahn, Hong Yup; Jeon, Won Seon; Jin, Sang Man; Woo, Jeong taek; Cha, Bong Soo; Kim, Jae Hyeon; Park, Cheol Young; Lee, Byung Wan.

In: Clinica Chimica Acta, Vol. 437, 01.11.2014, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults

T2 - A retrospective study based on the oral glucose tolerance test

AU - Hwang, You Cheol

AU - Jung, Chang Hee

AU - Ahn, Hong Yup

AU - Jeon, Won Seon

AU - Jin, Sang Man

AU - Woo, Jeong taek

AU - Cha, Bong Soo

AU - Kim, Jae Hyeon

AU - Park, Cheol Young

AU - Lee, Byung Wan

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Introduction: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-diabetes and diabetes in Korean adults. In addition, we compared the performance of GA for the diagnosis of diabetes with that of glycated hemoglobin (A1c). Materials and methods: A total of 852 subjects (498 males, 354 females) aged 20 to 83. years (mean: 52.5. years) were enrolled. A 75-g oral glucose tolerance test (OGTT) was performed and A1c and GA were measured. Results: In these enrolled subjects, 88% have glucose intolerance status (pre-diabetes or diabetes). The GA concentrations corresponding to fasting plasma glucose (FPG) of 7.0. mmol/l, 2-h plasma glucose during OGTT (PPG2). ≥. 11.1. mmol/l, and A1c. ≥. 6.5% were 14.6%, 13.7%, and 14.7%, respectively. A meta-analysis of three GA cutoffs revealed a GA cutoff for diabetes of 14.3%. When A1c is used in combination with FPG, the sensitivity and specificity for the diagnosis of OGTT-based diabetes were 72.16% (95% CI: 66.6-72.2) and 96.4% (95% CI: 94.4-97.7), respectively. With the newly developed GA cutoff of 14.3%, GA combined with FPG resulted in a sensitivity and specificity of 77.5% (95% CI: 72.17-82.0) and 89.9% (95% CI: 87.1-92.2), respectively. Conclusions: A GA cutoff of >. 14.3% is optimal for the diagnosis of diabetes in Korean adults. The measurement of FPG and GA may detect diabetes earlier than the measurement of FPG and A1c.

AB - Introduction: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-diabetes and diabetes in Korean adults. In addition, we compared the performance of GA for the diagnosis of diabetes with that of glycated hemoglobin (A1c). Materials and methods: A total of 852 subjects (498 males, 354 females) aged 20 to 83. years (mean: 52.5. years) were enrolled. A 75-g oral glucose tolerance test (OGTT) was performed and A1c and GA were measured. Results: In these enrolled subjects, 88% have glucose intolerance status (pre-diabetes or diabetes). The GA concentrations corresponding to fasting plasma glucose (FPG) of 7.0. mmol/l, 2-h plasma glucose during OGTT (PPG2). ≥. 11.1. mmol/l, and A1c. ≥. 6.5% were 14.6%, 13.7%, and 14.7%, respectively. A meta-analysis of three GA cutoffs revealed a GA cutoff for diabetes of 14.3%. When A1c is used in combination with FPG, the sensitivity and specificity for the diagnosis of OGTT-based diabetes were 72.16% (95% CI: 66.6-72.2) and 96.4% (95% CI: 94.4-97.7), respectively. With the newly developed GA cutoff of 14.3%, GA combined with FPG resulted in a sensitivity and specificity of 77.5% (95% CI: 72.17-82.0) and 89.9% (95% CI: 87.1-92.2), respectively. Conclusions: A GA cutoff of >. 14.3% is optimal for the diagnosis of diabetes in Korean adults. The measurement of FPG and GA may detect diabetes earlier than the measurement of FPG and A1c.

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