Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Soo Hee Choi, Jae Jin Kim, Jae Yong Choi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

To determine the optimal acquisition time of [18F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40min and there was a strong correlation between DVR and SUVR in the 60-80min. Therefore, we recommend the use of a single time point between 60 and 80min for [18F]Mefway static PET.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalApplied Radiation and Isotopes
Volume107
DOIs
Publication statusPublished - 2016 Jan 1

Bibliographical note

Funding Information:
This study was supported by a 2014 faculty research Grant from Yonsei University College of Medicine ( 6-2014-0030 ).

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Radiation

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