Optimal Voltage and Electrical Pulse Conditions for Electrical Ablation to Induce Immunogenic Cell Death (ICD)

Eun Jin Go, Dasom Yang, Won Hyoung Ryu, Hong Jae Chon, Chan Kim, Kyung Soon Park, Dong Hyun Kim, Dong Keun Han, Wooram Park

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissue surrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death (ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage and pulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate the ablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vitro under two- and three-dimensional conditions to assess cell viability under different voltage and pulse conditions. Additionally, the expression of damage-associated molecular pattern (DAMP) markers of ICD was measured to identify an optimal voltage condition. Tumor volume, body weight, and survival after EA treatment were measured in vivo to identify the optimal pulse conditions. The optimal conditions to induce ICD by EA identified in this study are suitable to be combined with cancer immunotherapy.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalJournal of Industrial and Engineering Chemistry
Publication statusPublished - 2021 Feb 25

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) of Korea. The grant was funded by the Ministry of Science and ICT (MSIT), Republic of Korea ( 2018R1C1B6001120 , 2019R1A6A1A03032888 , 2020M2D9A3094208 , and 2020R1A2B5B03002344 ).

Publisher Copyright:
© 2020 The Korean Society of Industrial and Engineering Chemistry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


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