Optimization of extraction conditions for active compounds of herbal medicinal formula, DF, by response surface methodology

Birang Jeong; Seong Yeon Choi; Hyeon Seok Jang; Guijae Yoo; Seung Hyun Kim; Jung Hwan Kim; Yong Soo Kwon; Jong Seong Roh; Yoosik Yoon; Soon Shik Shin; Heejung Yang

doi:10.20307/nps.2017.23.1.9

Optimization of extraction conditions for active compounds of herbal medicinal formula, DF, by response surface methodology

Birang Jeong, Seong Yeon Choi, Hyeon Seok Jang, Guijae Yoo, Seung Hyun Kim, Jung Hwan Kim, Yong Soo Kwon, Jong Seong Roh, Yoosik Yoon, Soon Shik Shin, Heejung Yang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Natural Product Sciences
Volume	23
Issue number	1
DOIs	https://doi.org/10.20307/nps.2017.23.1.9
Publication status	Published - 2017

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI15C0075) and by the 2014 Research Grant from Kangwon National University (No. 120140653).

Publisher Copyright:
© 2017, Korean Society of Pharmacognosy. All rights reserved.

All Science Journal Classification (ASJC) codes

Drug Discovery
Organic Chemistry

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10.20307/nps.2017.23.1.9

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title = "Optimization of extraction conditions for active compounds of herbal medicinal formula, DF, by response surface methodology",

abstract = "DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.",

author = "Birang Jeong and Choi, {Seong Yeon} and Jang, {Hyeon Seok} and Guijae Yoo and Kim, {Seung Hyun} and Kim, {Jung Hwan} and Kwon, {Yong Soo} and Roh, {Jong Seong} and Yoosik Yoon and Shin, {Soon Shik} and Heejung Yang",

note = "Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI15C0075) and by the 2014 Research Grant from Kangwon National University (No. 120140653). Publisher Copyright: {\textcopyright} 2017, Korean Society of Pharmacognosy. All rights reserved.",

year = "2017",

doi = "10.20307/nps.2017.23.1.9",

language = "English",

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AU - Jeong, Birang

AU - Choi, Seong Yeon

AU - Jang, Hyeon Seok

AU - Yoo, Guijae

AU - Kim, Seung Hyun

AU - Kim, Jung Hwan

AU - Kwon, Yong Soo

AU - Roh, Jong Seong

AU - Yoon, Yoosik

AU - Shin, Soon Shik

AU - Yang, Heejung

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI15C0075) and by the 2014 Research Grant from Kangwon National University (No. 120140653). Publisher Copyright: © 2017, Korean Society of Pharmacognosy. All rights reserved.

PY - 2017

Y1 - 2017

N2 - DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.

AB - DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.

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Optimization of extraction conditions for active compounds of herbal medicinal formula, DF, by response surface methodology

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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