Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)

Eunah Ko; Kanghwan Kim; Mihaly Voroslakos; Sungjin Oh; Gyorgy Buzsaki; Kensall D. Wise; Euisk Yoon

doi:10.1109/IEDM45625.2022.10019379

Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)

Eunah Ko, Kanghwan Kim, Mihaly Voroslakos, Sungjin Oh, Gyorgy Buzsaki, Kensall D. Wise, Euisk Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Evolution of 'Michigan Probes' has enabled unraveling the connectivity of neurons at cellular resolution and their dynamic interaction within and across brain areas that underlie behavioral and cognitive functions. Recently, micro-LEDs were monolithically integrated for optogenetic neuromodulation at scale without requiring external optical fiber connection. The 'hectoSTAR' micro-LED optoelectrode features 256 recording electrodes and 128 stimulation micro-LEDs in four silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. Technical challenges to overcome in scaling of optogenetic probes will be discussed, followed by future direction.

Original language	English
Title of host publication	2022 International Electron Devices Meeting, IEDM 2022
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2911-2914
Number of pages	4
ISBN (Electronic)	9781665489591
DOIs	https://doi.org/10.1109/IEDM45625.2022.10019379
Publication status	Published - 2022
Event	2022 International Electron Devices Meeting, IEDM 2022 - San Francisco, United States Duration: 2022 Dec 3 → 2022 Dec 7

Publication series

Name	Technical Digest - International Electron Devices Meeting, IEDM
Volume	2022-December
ISSN (Print)	0163-1918

Conference

Conference	2022 International Electron Devices Meeting, IEDM 2022
Country/Territory	United States
City	San Francisco
Period	22/12/3 → 22/12/7

Bibliographical note

Funding Information:
ACKNOWLEDGMENT The authors gratefully acknowledge the support of grants: NIH 1RF1NS113283-01, NSF 1545858, NSF 1707316, U19 NS104590, MH107396, and NIH 4R00MH120343-03. M. V., G. B., and E. Y. are supported by the Kavli Foundation. S. O. is supported by Fulbright Scholarship.

Publisher Copyright:
© 2022 IEEE.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Materials Chemistry
Electrical and Electronic Engineering

Access to Document

10.1109/IEDM45625.2022.10019379

Cite this

Ko, E., Kim, K., Voroslakos, M., Oh, S., Buzsaki, G., Wise, K. D., & Yoon, E. (2022). Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited). In 2022 International Electron Devices Meeting, IEDM 2022 (pp. 2911-2914). (Technical Digest - International Electron Devices Meeting, IEDM; Vol. 2022-December). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IEDM45625.2022.10019379

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title = "Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)",

abstract = "Evolution of 'Michigan Probes' has enabled unraveling the connectivity of neurons at cellular resolution and their dynamic interaction within and across brain areas that underlie behavioral and cognitive functions. Recently, micro-LEDs were monolithically integrated for optogenetic neuromodulation at scale without requiring external optical fiber connection. The 'hectoSTAR' micro-LED optoelectrode features 256 recording electrodes and 128 stimulation micro-LEDs in four silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. Technical challenges to overcome in scaling of optogenetic probes will be discussed, followed by future direction.",

author = "Eunah Ko and Kanghwan Kim and Mihaly Voroslakos and Sungjin Oh and Gyorgy Buzsaki and Wise, {Kensall D.} and Euisk Yoon",

note = "Funding Information: ACKNOWLEDGMENT The authors gratefully acknowledge the support of grants: NIH 1RF1NS113283-01, NSF 1545858, NSF 1707316, U19 NS104590, MH107396, and NIH 4R00MH120343-03. M. V., G. B., and E. Y. are supported by the Kavli Foundation. S. O. is supported by Fulbright Scholarship. Publisher Copyright: {\textcopyright} 2022 IEEE.; 2022 International Electron Devices Meeting, IEDM 2022 ; Conference date: 03-12-2022 Through 07-12-2022",

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doi = "10.1109/IEDM45625.2022.10019379",

language = "English",

series = "Technical Digest - International Electron Devices Meeting, IEDM",

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Ko, E, Kim, K, Voroslakos, M, Oh, S, Buzsaki, G, Wise, KD & Yoon, E 2022, Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited). in 2022 International Electron Devices Meeting, IEDM 2022. Technical Digest - International Electron Devices Meeting, IEDM, vol. 2022-December, Institute of Electrical and Electronics Engineers Inc., pp. 2911-2914, 2022 International Electron Devices Meeting, IEDM 2022, San Francisco, United States, 22/12/3. https://doi.org/10.1109/IEDM45625.2022.10019379

Optogenetic Neural Probes : Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited). / Ko, Eunah; Kim, Kanghwan; Voroslakos, Mihaly et al.

2022 International Electron Devices Meeting, IEDM 2022. Institute of Electrical and Electronics Engineers Inc., 2022. p. 2911-2914 (Technical Digest - International Electron Devices Meeting, IEDM; Vol. 2022-December).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Ko E, Kim K, Voroslakos M, Oh S, Buzsaki G, Wise KD et al. Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited). In 2022 International Electron Devices Meeting, IEDM 2022. Institute of Electrical and Electronics Engineers Inc. 2022. p. 2911-2914. (Technical Digest - International Electron Devices Meeting, IEDM). doi: 10.1109/IEDM45625.2022.10019379

Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)

Abstract

Publication series

Conference

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

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Cite this