Optogenetically induced sleep spindle rhythms alter sleep architectures in mice

Angela Kim; Charles Latchoumane; Soojung Lee; Guk Bae Kim; Eunji Cheong; George J. Augustine; Hee Sup Shin

doi:10.1073/pnas.1217897109

Optogenetically induced sleep spindle rhythms alter sleep architectures in mice

Angela Kim, Charles Latchoumane, Soojung Lee, Guk Bae Kim, Eunji Cheong, George J. Augustine, Hee Sup Shin

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation.

Original language	English
Pages (from-to)	20673-20678
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	50
DOIs	https://doi.org/10.1073/pnas.1217897109
Publication status	Published - 2012 Dec 11

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS. This work was supported by grants from Institute for Basic Science, the National Honor Scientist Program of Korea, and the World Class Institute (WCI) Program of the National Research Foundation of Korea (NRF) (WCI 2009-003) funded by the Ministry of Education, Science and Technology of Korea (MEST) and by a Competitive Research Program grant from the National Research Foundation of Singapore.

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1073/pnas.1217897109

Cite this

@article{dcd9414c4d3e4b2aacefd6f59f1c43f6,

title = "Optogenetically induced sleep spindle rhythms alter sleep architectures in mice",

abstract = "Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation.",

author = "Angela Kim and Charles Latchoumane and Soojung Lee and Kim, {Guk Bae} and Eunji Cheong and Augustine, {George J.} and Shin, {Hee Sup}",

note = "Funding Information: ACKNOWLEDGMENTS. This work was supported by grants from Institute for Basic Science, the National Honor Scientist Program of Korea, and the World Class Institute (WCI) Program of the National Research Foundation of Korea (NRF) (WCI 2009-003) funded by the Ministry of Education, Science and Technology of Korea (MEST) and by a Competitive Research Program grant from the National Research Foundation of Singapore.",

year = "2012",

month = dec,

day = "11",

doi = "10.1073/pnas.1217897109",

language = "English",

volume = "109",

pages = "20673--20678",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "50",

}

Optogenetically induced sleep spindle rhythms alter sleep architectures in mice. / Kim, Angela; Latchoumane, Charles; Lee, Soojung; Kim, Guk Bae; Cheong, Eunji; Augustine, George J.; Shin, Hee Sup.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 50, 11.12.2012, p. 20673-20678.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Optogenetically induced sleep spindle rhythms alter sleep architectures in mice

AU - Kim, Angela

AU - Latchoumane, Charles

AU - Lee, Soojung

AU - Kim, Guk Bae

AU - Cheong, Eunji

AU - Augustine, George J.

AU - Shin, Hee Sup

N1 - Funding Information: ACKNOWLEDGMENTS. This work was supported by grants from Institute for Basic Science, the National Honor Scientist Program of Korea, and the World Class Institute (WCI) Program of the National Research Foundation of Korea (NRF) (WCI 2009-003) funded by the Ministry of Education, Science and Technology of Korea (MEST) and by a Competitive Research Program grant from the National Research Foundation of Singapore.

PY - 2012/12/11

Y1 - 2012/12/11

N2 - Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation.

AB - Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation.

UR - http://www.scopus.com/inward/record.url?scp=84874436363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874436363&partnerID=8YFLogxK

U2 - 10.1073/pnas.1217897109

DO - 10.1073/pnas.1217897109

M3 - Article

C2 - 23169668

AN - SCOPUS:84874436363

VL - 109

SP - 20673

EP - 20678

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 50

ER -

Optogenetically induced sleep spindle rhythms alter sleep architectures in mice

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this