Optogenetically induced sleep spindle rhythms alter sleep architectures in mice

Angela Kim, Charles Latchoumane, Soojung Lee, Guk Bae Kim, Eunji Cheong, George J. Augustine, Hee Sup Shin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation.

Original languageEnglish
Pages (from-to)20673-20678
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number50
DOIs
Publication statusPublished - 2012 Dec 11

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Sleep
Eye Movements
Optogenetics
Thalamic Nuclei

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, Angela ; Latchoumane, Charles ; Lee, Soojung ; Kim, Guk Bae ; Cheong, Eunji ; Augustine, George J. ; Shin, Hee Sup. / Optogenetically induced sleep spindle rhythms alter sleep architectures in mice. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 50. pp. 20673-20678.
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Optogenetically induced sleep spindle rhythms alter sleep architectures in mice. / Kim, Angela; Latchoumane, Charles; Lee, Soojung; Kim, Guk Bae; Cheong, Eunji; Augustine, George J.; Shin, Hee Sup.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 50, 11.12.2012, p. 20673-20678.

Research output: Contribution to journalArticle

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