Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose

In hwan Baek, Jung Soo Kim, Eun Sol Ha, Gwang Ho Choo, Wonkyung Cho, Sung Joo Hwang, Min Soo Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to develop a novel valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose (HPMC) with enhanced oral absorption. The valsartan-loaded redispersible dry emulsion was prepared by using a high-pressure homogenization and spray-drying process with water, Capryol 90, HPMC, and different surfactants, based on the results of the solubility study. The spray-dried emulsions formed small and homogeneous emulsions with a mean droplet emulsion size ranging from 133.5 to 152.5. nm at the dispersion state in water. The valsartan-loaded redispersible dry emulsion with HPMC/poloxamer 407 showed enhanced pH-independent valsartan release, resulting in a dramatically enhanced oral bioavailability of valsartan compared to the raw material and commercial product. Therefore, a formulation strategy using the redispersible dry emulsion with HPMC/poloxamer 407 is very effective for the development of a new dosage form containing valsartan.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume69
DOIs
Publication statusPublished - 2014 Aug

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

Fingerprint Dive into the research topics of 'Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose'. Together they form a unique fingerprint.

  • Cite this