Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose

In hwan Baek, Jung Soo Kim, Eun Sol Ha, Gwang Ho Choo, Wonkyung Cho, Sung Joo Hwang, Min Soo Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to develop a novel valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose (HPMC) with enhanced oral absorption. The valsartan-loaded redispersible dry emulsion was prepared by using a high-pressure homogenization and spray-drying process with water, Capryol 90, HPMC, and different surfactants, based on the results of the solubility study. The spray-dried emulsions formed small and homogeneous emulsions with a mean droplet emulsion size ranging from 133.5 to 152.5. nm at the dispersion state in water. The valsartan-loaded redispersible dry emulsion with HPMC/poloxamer 407 showed enhanced pH-independent valsartan release, resulting in a dramatically enhanced oral bioavailability of valsartan compared to the raw material and commercial product. Therefore, a formulation strategy using the redispersible dry emulsion with HPMC/poloxamer 407 is very effective for the development of a new dosage form containing valsartan.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume69
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Valsartan
Emulsions
Cellulose
Poloxamer
Spray drying
Water
Dosage Forms
Surface-Active Agents
Solubility
Biological Availability
Raw materials

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Cite this

Baek, In hwan ; Kim, Jung Soo ; Ha, Eun Sol ; Choo, Gwang Ho ; Cho, Wonkyung ; Hwang, Sung Joo ; Kim, Min Soo. / Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose. In: International Journal of Biological Macromolecules. 2014 ; Vol. 69. pp. 222-228.
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Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose. / Baek, In hwan; Kim, Jung Soo; Ha, Eun Sol; Choo, Gwang Ho; Cho, Wonkyung; Hwang, Sung Joo; Kim, Min Soo.

In: International Journal of Biological Macromolecules, Vol. 69, 01.01.2014, p. 222-228.

Research output: Contribution to journalArticle

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AU - Hwang, Sung Joo

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