Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers

Min Soo Kim, Jeong Soo Kim, Wonkyung Cho, Hee Jun Park, Sung Joo Hwang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalInternational Journal of Biological Macromolecules
Volume59
DOIs
Publication statusPublished - 2013 Aug 1

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Pyrrolidinones
Cellulose
Supersaturation
Polymers
Derivatives
Dispersions
Povidone
Rats
Dissolution
Atorvastatin Calcium
Water

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

Cite this

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abstract = "The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.",
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Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers. / Kim, Min Soo; Kim, Jeong Soo; Cho, Wonkyung; Park, Hee Jun; Hwang, Sung Joo.

In: International Journal of Biological Macromolecules, Vol. 59, 01.08.2013, p. 138-142.

Research output: Contribution to journalArticle

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