Orally administered 6:2 chlorinated polyfluorinated ether sulfonate (f-53b) causes thyroid dysfunction in rats

So Hye Hong, Seung Hee Lee, Jun Young Yang, Jin Hee Lee, Ki Kyung Jung, Ji Hyun Seok, Sung Hee Kim, Ki Taek Nam, Jayoung Jeong, Jong Kwon Lee, Jae Ho Oh

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9 Citations (Scopus)


The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expected to increase. Therefore, in this study, we performed a subchronic oral toxicity study of F-53B in Sprague Dawley (SD) rats. F-53B was administered orally once daily to male and female rats for 28 days at doses of 5, 20, and 100 mg/kg/day. There were no toxicologically significant changes in F-53B-treated rats, except in the thyroid gland. However, F-53B slightly reduced the serum concentrations of thyroid hormones, including triiodothyronine and thyroxine, compared with their concentrations in the vehicle group. F-53B also induced follicular hyperplasia and was associated with increased thyroid hormone biosynthesis-associated protein expression. These results demonstrate that F-53B is a strong regulator of thyroid hormones in SD rats as it disrupts thyroid function. Thus, caution should be exercised in the industrial application of F-53B as an alternative for PFOS.

Original languageEnglish
Article number54
Pages (from-to)1-10
Number of pages10
Issue number3
Publication statusPublished - 2020 Sept

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Chemical Health and Safety
  • Health, Toxicology and Mutagenesis


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