Organically modified sols as pseudostationary phases for microchip electrophoresis

Martin Pumera, Joseph Wang, Eli Grushka, Ovadia Lev

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We demonstrate that the selectivity of microchip electrophoresis separations is greatly improved by the presence of organically modified silica (Ormosil) sols in the run buffer. A negatively-charged N-(trimethoxysilylpropyl)ethylenediamine triacetic-acid (TETT)-based sol is used for improving the selectivity between nitroaromatic explosives and a methyltrimethoxysilane (MTMOS)-based sol is employed for enhancing the microchip separation of environmental pollutants, aminophenols. These sols are added to the run buffer and act as pseudostationary phases. Their presence in the run buffer changes the apparent mobility of studied solutes, and leads to a higher resolution. The observed mobilities changes reflect the interactions between the Ormosil sols and the solutes. Relevant experimental variables have been characterized and optimized. The diverse chemistry of Ormosil sols should be extremely useful for tailoring the selectivity of a wide range of electrophoresis microchip separations.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalTalanta
Volume72
Issue number2
DOIs
Publication statusPublished - 2007 Apr 30

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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