Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling

Su Kyeom Kim, Yu Heun Kim, Sewon Park, Seung Woo Cho

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

As life expectancy improves and the number of people suffering from various diseases increases, the need for developing effective personalized disease models is rapidly rising. The development of organoid technology has led to better recapitulation of the in vivo environment of organs, and can overcome the constraints of existing disease models. However, for more precise disease modeling, engineering approaches such as microfluidics and biomaterials, that aid in mimicking human physiology, need to be integrated with the organoid models. In this review, we introduce key elements for disease modeling and recent engineering advances using both liver and lung organoids. Due to the importance of personalized medicine, we also emphasize patient-derived cancer organoid models and their engineering approaches. These organoid-based disease models combined with microfluidics, biomaterials, and co-culture systems will provide a powerful research platform for understanding disease mechanisms and developing precision medicine; enabling preclinical drug screening and drug development. Statement of significance: The development of organoid technology has led to better recapitulation of the in vivo environment of organs, and can overcome the constraints of existing disease models. However, for more precise disease modeling, engineering approaches such as microfluidics and biomaterials, that aid in mimicking human physiology, need to be integrated with the organoid models. In this review, we introduce liver, lung, and cancer organoids integrated with various engineering approaches as a novel platform for personalized disease modeling. These engineered organoid-based disease models will provide a powerful research platform for understanding disease mechanisms and developing precision medicine.

Original languageEnglish
Pages (from-to)37-51
Number of pages15
JournalActa Biomaterialia
Volume132
DOIs
Publication statusPublished - 2021 Sep 15

Bibliographical note

Funding Information:
This work was supported by a grant ( 19172MFDS168 ) funded by the Ministry of Food and Drug Safety (MFDS) , Republic of Korea. This work was also supported by a grant ( 2018M3A9H1021382 ) from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT) , Republic of Korea.

Publisher Copyright:
© 2021 Acta Materialia Inc.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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