Organoid culture is a fast-emerging technology in the biological and biomedical research fields, garnering interest due to its unique features of self-organization from diverse types of stem cells and close resemblance to organs in the human body. This innovative in vitro model system presents the possibility of significant advances in the understanding of human development and disease mechanisms as well as in the discovery of novel diagnostics and therapeutics. Here, the authors review several types of tissue-specific organoids and discuss the most recent studies on the biomedical application of organoids. Finally, the challenges and prospects of organoids as an in vitro model system are laid out.
Bibliographical noteFunding Information:
This work was supported by grants (2017M3C7A1047659 and 2018M3A9H1021382) from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT), Republic of Korea.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Pharmaceutical Science
- Biochemistry, medical
- Pharmacology (medical)