Origami-paper-based device for microvesicle/exosome preconcentration and isolation

Hyerin Kim, Kyu Hyoung Lee, Sung Il Han, Dongho Lee, Seok Chung, Dohwan Lee, Jeong Hoon Lee

Research output: Contribution to journalArticle

Abstract

Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.

Original languageEnglish
Pages (from-to)3917-3921
Number of pages5
JournalLab on a chip
Volume19
Issue number23
DOIs
Publication statusPublished - 2019 Jan 1

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Exosomes
Biomarkers
Equipment and Supplies
Biopsy
Ions
Polarization
Liquids

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Kim, H., Lee, K. H., Han, S. I., Lee, D., Chung, S., Lee, D., & Lee, J. H. (2019). Origami-paper-based device for microvesicle/exosome preconcentration and isolation. Lab on a chip, 19(23), 3917-3921. https://doi.org/10.1039/c9lc00796b
Kim, Hyerin ; Lee, Kyu Hyoung ; Han, Sung Il ; Lee, Dongho ; Chung, Seok ; Lee, Dohwan ; Lee, Jeong Hoon. / Origami-paper-based device for microvesicle/exosome preconcentration and isolation. In: Lab on a chip. 2019 ; Vol. 19, No. 23. pp. 3917-3921.
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Kim, H, Lee, KH, Han, SI, Lee, D, Chung, S, Lee, D & Lee, JH 2019, 'Origami-paper-based device for microvesicle/exosome preconcentration and isolation', Lab on a chip, vol. 19, no. 23, pp. 3917-3921. https://doi.org/10.1039/c9lc00796b

Origami-paper-based device for microvesicle/exosome preconcentration and isolation. / Kim, Hyerin; Lee, Kyu Hyoung; Han, Sung Il; Lee, Dongho; Chung, Seok; Lee, Dohwan; Lee, Jeong Hoon.

In: Lab on a chip, Vol. 19, No. 23, 01.01.2019, p. 3917-3921.

Research output: Contribution to journalArticle

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AU - Lee, Dohwan

AU - Lee, Jeong Hoon

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