Abstract
Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
| Original language | English |
|---|---|
| Pages (from-to) | 3917-3921 |
| Number of pages | 5 |
| Journal | Lab on a chip |
| Volume | 19 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
Cite this
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Origami-paper-based device for microvesicle/exosome preconcentration and isolation. / Kim, Hyerin; Lee, Kyu Hyoung; Han, Sung Il; Lee, Dongho; Chung, Seok; Lee, Dohwan; Lee, Jeong Hoon.
In: Lab on a chip, Vol. 19, No. 23, 01.01.2019, p. 3917-3921.Research output: Contribution to journal › Article
TY - JOUR
T1 - Origami-paper-based device for microvesicle/exosome preconcentration and isolation
AU - Kim, Hyerin
AU - Lee, Kyu Hyoung
AU - Han, Sung Il
AU - Lee, Dongho
AU - Chung, Seok
AU - Lee, Dohwan
AU - Lee, Jeong Hoon
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
AB - Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
UR - http://www.scopus.com/inward/record.url?scp=85075228091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075228091&partnerID=8YFLogxK
U2 - 10.1039/c9lc00796b
DO - 10.1039/c9lc00796b
M3 - Article
C2 - 31650155
AN - SCOPUS:85075228091
VL - 19
SP - 3917
EP - 3921
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 23
ER -