Ortho alkylation of aromatic ketimine with functionalized alkene by Rh(I) catalyst

Sung Gon Lim; Jeong Ae Ahn; Chui Ho Jun

doi:10.1021/ol048095n

Ortho alkylation of aromatic ketimine with functionalized alkene by Rh(I) catalyst

Sung Gon Lim, Jeong Ae Ahn, Chui Ho Jun

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

(Chemical Equation Presented) The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh ₃)₃RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.

Original language	English
Pages (from-to)	4687-4690
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	25
DOIs	https://doi.org/10.1021/ol048095n
Publication status	Published - 2004 Dec 9

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "(Chemical Equation Presented) The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh 3)3RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.",

author = "Lim, {Sung Gon} and Ahn, {Jeong Ae} and Jun, {Chui Ho}",

year = "2004",

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N2 - (Chemical Equation Presented) The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh 3)3RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.

AB - (Chemical Equation Presented) The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh 3)3RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.

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Ortho alkylation of aromatic ketimine with functionalized alkene by Rh(I) catalyst

Abstract

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