Osteophilic multilayer coatings for accelerated bone tissue growth

Nisarg J. Shah, Jinkee Hong, Md Nasim Hyder, Paula T. Hammond

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)


Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

Original languageEnglish
Pages (from-to)1445-1450
Number of pages6
JournalAdvanced Materials
Issue number11
Publication statusPublished - 2012 Mar 15

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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