Abstract
Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.
| Original language | English |
|---|---|
| Pages (from-to) | 1445-1450 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 24 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2012 Mar 15 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
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Osteophilic multilayer coatings for accelerated bone tissue growth. / Shah, Nisarg J.; Hong, Jinkee; Hyder, Md Nasim; Hammond, Paula T.
In: Advanced Materials, Vol. 24, No. 11, 15.03.2012, p. 1445-1450.Research output: Contribution to journal › Article
TY - JOUR
T1 - Osteophilic multilayer coatings for accelerated bone tissue growth
AU - Shah, Nisarg J.
AU - Hong, Jinkee
AU - Hyder, Md Nasim
AU - Hammond, Paula T.
PY - 2012/3/15
Y1 - 2012/3/15
N2 - Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.
AB - Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.
UR - http://www.scopus.com/inward/record.url?scp=84858311457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858311457&partnerID=8YFLogxK
U2 - 10.1002/adma.201104475
DO - 10.1002/adma.201104475
M3 - Article
C2 - 22311551
AN - SCOPUS:84858311457
VL - 24
SP - 1445
EP - 1450
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 11
ER -