Osteophilic multilayer coatings for accelerated bone tissue growth

Nisarg J. Shah, Jinkee Hong, Md Nasim Hyder, Paula T. Hammond

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

Original languageEnglish
Pages (from-to)1445-1450
Number of pages6
JournalAdvanced Materials
Volume24
Issue number11
DOIs
Publication statusPublished - 2012 Mar 15

Fingerprint

Stem cells
Bone
Multilayers
Tissue
Natural polymers
Coatings
Bone Morphogenetic Proteins
Osteoblasts
Orthopedics
Chitosan
Durapatite
Hydroxyapatite
Esters
Nanoparticles
Proteins

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shah, Nisarg J. ; Hong, Jinkee ; Hyder, Md Nasim ; Hammond, Paula T. / Osteophilic multilayer coatings for accelerated bone tissue growth. In: Advanced Materials. 2012 ; Vol. 24, No. 11. pp. 1445-1450.
@article{91df3baad7f147fc9948706fca999ee3,
title = "Osteophilic multilayer coatings for accelerated bone tissue growth",
abstract = "Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.",
author = "Shah, {Nisarg J.} and Jinkee Hong and Hyder, {Md Nasim} and Hammond, {Paula T.}",
year = "2012",
month = "3",
day = "15",
doi = "10.1002/adma.201104475",
language = "English",
volume = "24",
pages = "1445--1450",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "11",

}

Osteophilic multilayer coatings for accelerated bone tissue growth. / Shah, Nisarg J.; Hong, Jinkee; Hyder, Md Nasim; Hammond, Paula T.

In: Advanced Materials, Vol. 24, No. 11, 15.03.2012, p. 1445-1450.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Osteophilic multilayer coatings for accelerated bone tissue growth

AU - Shah, Nisarg J.

AU - Hong, Jinkee

AU - Hyder, Md Nasim

AU - Hammond, Paula T.

PY - 2012/3/15

Y1 - 2012/3/15

N2 - Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

AB - Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

UR - http://www.scopus.com/inward/record.url?scp=84858311457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858311457&partnerID=8YFLogxK

U2 - 10.1002/adma.201104475

DO - 10.1002/adma.201104475

M3 - Article

C2 - 22311551

AN - SCOPUS:84858311457

VL - 24

SP - 1445

EP - 1450

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 11

ER -