Osteophilic multilayer coatings for accelerated bone tissue growth

Nisarg J. Shah; Jinkee Hong; Md Nasim Hyder; Paula T. Hammond

doi:10.1002/adma.201104475

Osteophilic multilayer coatings for accelerated bone tissue growth

Nisarg J. Shah, Jinkee Hong, Md Nasim Hyder, Paula T. Hammond

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

Original language	English
Pages (from-to)	1445-1450
Number of pages	6
Journal	Advanced Materials
Volume	24
Issue number	11
DOIs	https://doi.org/10.1002/adma.201104475
Publication status	Published - 2012 Mar 15

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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