Outcome of adjuvant therapy for gallbladder cancer

Hyung Soon Park, Jae Yun Lim, Dong Sup Yoon, Joon Seong Park, Dong Ki Lee, Se Joon Lee, Hye Jin Choi, Si Young Song, Woo Jung Lee, Jae Yong Cho

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Objectives: The aim of this study was to evaluate the outcome of adjuvant therapy on the overall survival (OS) and disease-free survival (DFS) after curative resection (RO) of patients with TNM stage II gallbladder (GB) cancer. Methods: A total of 160 patients who had received curative resection (RO) between January 2000 and December 2009 were retrospectively reviewed. Among 61 stage II GB cancer patients, 43 received adjuvant therapy, while 18 others received surgery alone. The median follow-up period was 27.3 months (range 2.2-98.9 months). Results: OS was not significantly different among the adjuvant therapies (p = 0.180), but DFS was (p = 0.033). The 3-year OS and DFS from surgery alone, adjuvant chemotherapy, adjuvant radiotherapy, and adjuvant concurrent chemo-radiotherapy were 64, 78, 36 and 36%, and 56, 69, 14 and 47%, respectively. Overall, the chemotherapy group had a better prognosis, although there were no significant differences. Conclusions: The data from this study do not provide evidence that adjuvant therapy is an effective treatment option for curative resected GB cancer. A large randomized controlled study is necessary to confirm the efficacy of adjuvant therapy. Newer adjuvant studies should be focused on gemcitabine-based chemotherapy or chemo-radiotherapy with molecular-based target agents.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalOncology
Volume79
Issue number3-4
DOIs
Publication statusPublished - 2011 Mar

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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