Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

Haeyoung Kim, Won Park, Su Ssan Kim, Sung Ja Ahn, Yong Bae Kim, Tae Hyun Kim, Jin Hee Kim, Jin Hwa Choi, Hae Jin Park, Jee Suk Chang, Doo Ho Choi

Research output: Contribution to journalArticle

Abstract

Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalBreast
Volume49
DOIs
Publication statusPublished - 2020 Feb

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Breast
Lymph Nodes
Magnetic Resonance Imaging
Breast Neoplasms
Neoplasm Metastasis
Therapeutics
Survival Rate
Recurrence
Lymph Node Excision
Disease-Free Survival
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kim, Haeyoung ; Park, Won ; Kim, Su Ssan ; Ahn, Sung Ja ; Kim, Yong Bae ; Kim, Tae Hyun ; Kim, Jin Hee ; Choi, Jin Hwa ; Park, Hae Jin ; Chang, Jee Suk ; Choi, Doo Ho. / Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI. In: Breast. 2020 ; Vol. 49. pp. 63-69.
@article{74128f53039c41d594e0b9285969790d,
title = "Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI",
abstract = "Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4{\%}, 92.1{\%}, and 96.8{\%}, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1{\%} vs. 75.0{\%}; p = 0.02). Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.",
author = "Haeyoung Kim and Won Park and Kim, {Su Ssan} and Ahn, {Sung Ja} and Kim, {Yong Bae} and Kim, {Tae Hyun} and Kim, {Jin Hee} and Choi, {Jin Hwa} and Park, {Hae Jin} and Chang, {Jee Suk} and Choi, {Doo Ho}",
year = "2020",
month = "2",
doi = "10.1016/j.breast.2019.10.017",
language = "English",
volume = "49",
pages = "63--69",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",

}

Kim, H, Park, W, Kim, SS, Ahn, SJ, Kim, YB, Kim, TH, Kim, JH, Choi, JH, Park, HJ, Chang, JS & Choi, DH 2020, 'Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI', Breast, vol. 49, pp. 63-69. https://doi.org/10.1016/j.breast.2019.10.017

Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI. / Kim, Haeyoung; Park, Won; Kim, Su Ssan; Ahn, Sung Ja; Kim, Yong Bae; Kim, Tae Hyun; Kim, Jin Hee; Choi, Jin Hwa; Park, Hae Jin; Chang, Jee Suk; Choi, Doo Ho.

In: Breast, Vol. 49, 02.2020, p. 63-69.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

AU - Kim, Haeyoung

AU - Park, Won

AU - Kim, Su Ssan

AU - Ahn, Sung Ja

AU - Kim, Yong Bae

AU - Kim, Tae Hyun

AU - Kim, Jin Hee

AU - Choi, Jin Hwa

AU - Park, Hae Jin

AU - Chang, Jee Suk

AU - Choi, Doo Ho

PY - 2020/2

Y1 - 2020/2

N2 - Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.

AB - Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.

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DO - 10.1016/j.breast.2019.10.017

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