Abstract
Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.
| Original language | English |
|---|---|
| Pages (from-to) | 1000-1006 |
| Number of pages | 7 |
| Journal | Journal of the American Society of Nephrology |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Nephrology
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Outcome of multipair donor kidney exchange by a web-based algorithm. / Kim, Beom Seok; Kim, YuSeun; Kim, Soon Il; Kim, Myoung Soo; Lee, Ho Yung; Kim, Yong Lim; Kim, Chan Duck; Yang, Chul Woo; Choi, Bum Soon; Han, Duck Jong; Kim, Yon Su; Kim, Sung Joo; Oh, Ha Young; Kim, Dae Joong.
In: Journal of the American Society of Nephrology, Vol. 18, No. 3, 01.03.2007, p. 1000-1006.Research output: Contribution to journal › Article
TY - JOUR
T1 - Outcome of multipair donor kidney exchange by a web-based algorithm
AU - Kim, Beom Seok
AU - Kim, YuSeun
AU - Kim, Soon Il
AU - Kim, Myoung Soo
AU - Lee, Ho Yung
AU - Kim, Yong Lim
AU - Kim, Chan Duck
AU - Yang, Chul Woo
AU - Choi, Bum Soon
AU - Han, Duck Jong
AU - Kim, Yon Su
AU - Kim, Sung Joo
AU - Oh, Ha Young
AU - Kim, Dae Joong
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.
AB - Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.
UR - http://www.scopus.com/inward/record.url?scp=33947316234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947316234&partnerID=8YFLogxK
U2 - 10.1681/ASN.2006101071
DO - 10.1681/ASN.2006101071
M3 - Article
C2 - 17267737
AN - SCOPUS:33947316234
VL - 18
SP - 1000
EP - 1006
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 3
ER -