Outcome predictors for intestinal Behçet's disease

Jae Jun Park, Won Ho Kim, JaeHee Cheon

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Behcet's disease (BD) is a multisystem inflammatory disorder that presents as recurrent oral and genital ulcers in conjunction with other dermatological and ocular manifestations. The prevalence of BD is higher in Middle and East Asia than in Western countries. Intestinal BD is a specific subtype of BD, characterized by intestinal ulcers and associated gastrointestinal symptoms. Similar to inflammatory bowel disease, intestinal BD exhibits a fluctuating disease course with repeated episodes of relapse and remission that necessitate adequate maintenance therapy after achievement of clinical remission. Medical treatment of intestinal BD is largely empirical since well-controlled studies have been difficult to perform due to the heterogeneity and rarity of the disease. To date, 5-aminosalicylic acid, systemic corticosteroids, and immunosuppressants have been used anecdotally to treat intestinal BD. The clinical course of intestinal BD shows considerable variability, and the exact point at which more potent agents such as immunosuppressants should be used has not yet been elucidated. Given the difficulty in predicting which patients will experience complicated disease courses and the fact that these drugs are related with certain risk resulting from immunosuppression, proper identification of prognostic factors in intestinal BD may allow physicians to implement tailored medical therapy and individualized patient monitoring based on risk stratification. In this review, the impact of baseline characteristics on the long-term course of intestinal BD, prognostic factors during various medical therapies, and outcome predictors related to surgery will be discussed.

Original languageEnglish
Pages (from-to)1084-1090
Number of pages7
JournalYonsei medical journal
Volume54
Issue number5
DOIs
Publication statusPublished - 2013 Sep 1

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Intestinal Diseases
Behcet Syndrome
Immunosuppressive Agents
Eye Manifestations
Oral Ulcer
Mesalamine
Middle East
Far East
Physiologic Monitoring
Therapeutics
Inflammatory Bowel Diseases
Immunosuppression
Ulcer
Adrenal Cortex Hormones
Physicians
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Jae Jun ; Kim, Won Ho ; Cheon, JaeHee. / Outcome predictors for intestinal Behçet's disease. In: Yonsei medical journal. 2013 ; Vol. 54, No. 5. pp. 1084-1090.
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Outcome predictors for intestinal Behçet's disease. / Park, Jae Jun; Kim, Won Ho; Cheon, JaeHee.

In: Yonsei medical journal, Vol. 54, No. 5, 01.09.2013, p. 1084-1090.

Research output: Contribution to journalReview article

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AB - Behcet's disease (BD) is a multisystem inflammatory disorder that presents as recurrent oral and genital ulcers in conjunction with other dermatological and ocular manifestations. The prevalence of BD is higher in Middle and East Asia than in Western countries. Intestinal BD is a specific subtype of BD, characterized by intestinal ulcers and associated gastrointestinal symptoms. Similar to inflammatory bowel disease, intestinal BD exhibits a fluctuating disease course with repeated episodes of relapse and remission that necessitate adequate maintenance therapy after achievement of clinical remission. Medical treatment of intestinal BD is largely empirical since well-controlled studies have been difficult to perform due to the heterogeneity and rarity of the disease. To date, 5-aminosalicylic acid, systemic corticosteroids, and immunosuppressants have been used anecdotally to treat intestinal BD. The clinical course of intestinal BD shows considerable variability, and the exact point at which more potent agents such as immunosuppressants should be used has not yet been elucidated. Given the difficulty in predicting which patients will experience complicated disease courses and the fact that these drugs are related with certain risk resulting from immunosuppression, proper identification of prognostic factors in intestinal BD may allow physicians to implement tailored medical therapy and individualized patient monitoring based on risk stratification. In this review, the impact of baseline characteristics on the long-term course of intestinal BD, prognostic factors during various medical therapies, and outcome predictors related to surgery will be discussed.

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