Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy

Yun Jin Lee, Joon Soo Lee, hoonchul kang, Dong Seok Kim, Kyu Won Shim, Soyong Eom, HeungDong Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: to evaluate the outcomes and role of epilepsy surgery in children with intractable epileptic encephalopathy (EE). Methods: ninety-five children (64 boys, 31 girls) with intractable EE were treated by epilepsy surgery at Severance Children's Hospital from 2003 to 2008. Surgical treatments included lobar resection, hemispherotomy and corpus callosotomy (CC). Seventy-six children were Lennox-Gastaut syndrome (LGS), and 19 had West syndrome. Results: of the 76 patients with LGS, CC was performed in 37 patients (48.7%), lobar resection in 29 (38.2%) and hemispherotomy in 10 (13.2%). Of the 19 patients with West syndrome, respective surgery was performed in 15 patients (78.9%) and CC in 4 (21.1%). Of the patients receiving respective surgery, Engel's class I outcomes were achieved for 24 of 39 (61.5%) of LGS patients, and for 9 of 15 (60.0%) of West syndrome. Malformations of cortical development were commonly observed, appearing in 73.5% (36/49). In neuropsychiatric tests, 19 of 27 with LGS demonstrated improvement in postoperative cognitive function. More significant intellectual improvement correlated well with shorter epilepsy duration, good seizure outcomes, and decreased number of antiepileptic drugs. Conclusions: epilepsy surgery should be considered in treating childhood intractable EE with expectation of improvement of both seizure and cognitive outcomes, even in cases of LGS.

Original languageEnglish
Pages (from-to)496-504
Number of pages9
JournalBrain and Development
Volume36
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Brain Diseases
Epilepsy
Infantile Spasms
Seizures
Malformations of Cortical Development
Anticonvulsants
Cognition
Lennox Gastaut Syndrome

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Lee, Yun Jin ; Lee, Joon Soo ; kang, hoonchul ; Kim, Dong Seok ; Shim, Kyu Won ; Eom, Soyong ; Kim, HeungDong. / Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy. In: Brain and Development. 2014 ; Vol. 36, No. 6. pp. 496-504.
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Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy. / Lee, Yun Jin; Lee, Joon Soo; kang, hoonchul; Kim, Dong Seok; Shim, Kyu Won; Eom, Soyong; Kim, HeungDong.

In: Brain and Development, Vol. 36, No. 6, 01.01.2014, p. 496-504.

Research output: Contribution to journalArticle

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