Outcomes of uterine sarcoma found incidentally after uterus-preserving surgery for presumed benign disease

Jung Yun Lee, Hyun Soo Kim, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The aims of this study were to evaluate the impact of initial uterus-preserving surgery, such as myomectomy or subtotal hysterectomy, on the recurrence rates of patients with uterine sarcoma found incidentally and to investigate the role of surgical re-exploration in this disease subset. Methods: We performed a retrospective chart review for patients who had previously undergone either total hysterectomy or subtotal hysterectomy or myomectomy at the time of initial surgery for presumed benign uterine leiomyoma and were found to have uterine sarcoma on final pathology. Survival analysis was performed comparing patients according to the type of initial surgery. Results: Between 2006 and 2014, 45 patients with uterine sarcoma were identified. Myomectomy or subtotal hysterectomy was performed in 15 patients, and 30 patients underwent total hysterectomy as the initial surgery. Of the patients who underwent myomectomy or subtotal hysterectomy as the initial surgery (n=15), 14 were re-explored to complete staging. Of the patients who underwent re-exploration (n=14), five (35.8 %) had remnant sarcoma on the remaining uterus and no patients had disseminated disease. A Kaplan-Meier curve and log-rank test showed no difference in progression-free survival (P=0.941) between the two groups. Conclusion: Initial uterus-preserving surgery does not appear to be associated with an adverse impact on survival outcomes for unexpected uterine sarcoma when surgical re-exploration was performed immediately. As such, surgical re-exploration may be useful for removing any remnant sarcoma.

Original languageEnglish
Article number675
JournalBMC cancer
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Aug 23

Fingerprint

Sarcoma
Uterus
Uterine Myomectomy
Hysterectomy
Leiomyoma
Survival Analysis
Disease-Free Survival
Pathology
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

Cite this

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title = "Outcomes of uterine sarcoma found incidentally after uterus-preserving surgery for presumed benign disease",
abstract = "Background: The aims of this study were to evaluate the impact of initial uterus-preserving surgery, such as myomectomy or subtotal hysterectomy, on the recurrence rates of patients with uterine sarcoma found incidentally and to investigate the role of surgical re-exploration in this disease subset. Methods: We performed a retrospective chart review for patients who had previously undergone either total hysterectomy or subtotal hysterectomy or myomectomy at the time of initial surgery for presumed benign uterine leiomyoma and were found to have uterine sarcoma on final pathology. Survival analysis was performed comparing patients according to the type of initial surgery. Results: Between 2006 and 2014, 45 patients with uterine sarcoma were identified. Myomectomy or subtotal hysterectomy was performed in 15 patients, and 30 patients underwent total hysterectomy as the initial surgery. Of the patients who underwent myomectomy or subtotal hysterectomy as the initial surgery (n=15), 14 were re-explored to complete staging. Of the patients who underwent re-exploration (n=14), five (35.8 {\%}) had remnant sarcoma on the remaining uterus and no patients had disseminated disease. A Kaplan-Meier curve and log-rank test showed no difference in progression-free survival (P=0.941) between the two groups. Conclusion: Initial uterus-preserving surgery does not appear to be associated with an adverse impact on survival outcomes for unexpected uterine sarcoma when surgical re-exploration was performed immediately. As such, surgical re-exploration may be useful for removing any remnant sarcoma.",
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Outcomes of uterine sarcoma found incidentally after uterus-preserving surgery for presumed benign disease. / Lee, Jung Yun; Kim, Hyun Soo; Nam, Eun Ji; Kim, Sang Wun; Kim, Sunghoon; Kim, Young Tae.

In: BMC cancer, Vol. 16, No. 1, 675, 23.08.2016.

Research output: Contribution to journalArticle

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AU - Kim, Young Tae

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