Ovarian mesonephric-like adenocarcinoma with multifocal microscopic involvement of the fimbrial surface: Potential for misdiagnosis of tubal intraepithelial metastasis as serous tubal intraepithelial carcinoma associated with ovarian high-grade serous carcinoma

Hyunjin Kim, Go Eun Bae, Yoon Yang Jung, Hyun Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: We describe a rare case of ovarian mesonephric-like adenocarcinoma (MLA) involving the fimbria and mimicking serous tubal intraepithelial carcinoma (STIC). Case Report: A 47-year-old woman presented with a 4.4-cm left ovarian mass. Histologically, the ovarian tumor showed papillary and solid architecture, severe nuclear pleomorphism, and increased mitotic activity. Some microscopic foci where the tumor cells spread horizontally along the fimbrial surface epithelium were noted, compatible with STIC. We initially considered the ovarian tumor to be high-grade serous carcinoma accompanied by a fimbrial STIC. However, immunostaining revealed nuclear immunoreactivity for paired box 2 and GATA-binding protein 3, but lacked expression of Wilms tumor 1. A thorough slide review and additional immunostaining revealed architectural diversity, densely eosinophilic intraluminal secretions, and lack of hormone receptor expression, supporting the diagnosis of MLA. Conclusion: Microscopic intraepithelial metastases of the MLA to the fimbria mimic STIC. We recommend ancillary tests, such as immunostaining, in patients with ovarian tumors whenever possible, particularly for those with differential diagnosis of MLA and high-grade serous carcinoma.

Original languageEnglish
Pages (from-to)3613-3622
Number of pages10
JournalIn Vivo
Volume35
Issue number6
DOIs
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2019R1G1A1100578).

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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