Overcoming Depression by Inhibition of Neural Burst Firing

Daesoo Kim, Eunji Cheong, Hee Sup Shin

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Abstract

The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression. The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

Original languageEnglish
Pages (from-to)878-879
Number of pages2
JournalNeuron
Volume98
Issue number5
DOIs
Publication statusPublished - 2018 Jun 6

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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