Overcoming Depression by Inhibition of Neural Burst Firing

Daesoo Kim, Eunji Cheong, Hee Sup Shin

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)

Abstract

The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression. The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

Original languageEnglish
Pages (from-to)878-879
Number of pages2
JournalNeuron
Volume98
Issue number5
DOIs
Publication statusPublished - 2018 Jun 6

Bibliographical note

Funding Information:
Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning ( 2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science ( IBS-R001-D1 to H-S.S).

Funding Information:
Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science (IBS-R001-D1 to H-S.S).

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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