Overestimated oncologic significance of lymph node metastasis in G1 nonfunctioning neuroendocrine tumor in the left side of the pancreas

Young Jin Yoo, Seok Jeong Yang, Ho Kyoung Hwang, Chang Moo Kang, Hogeun Kim, Woo Jung Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recent studies have expounded on the oncologic significance of lymph node metastasis in nonfunctioning (NF) neuroendocrine tumors (NETs) of the pancreas and suggest regional lymph node dissection for treating pancreatic NET. We tested this recommendation in NF pancreatic NET-G1, as these tumors are generally small and suitable for function-preserving minimally invasive pancreatectomy. From January 2005 to December 2014, medical records of patients who underwent pancreatectomy for pathologically confirmed NF NETG1 of the left side of the pancreas were retrospectively reviewed. Oncologic outcomes were compared between limited pancreatectomy and distal pancreatosplenectomy. Thirty-five patients (14 males and 21 females) with a mean age of 55.9±11.4 years were enrolled in this study. Six patients (17.1%) underwent distal pancreatosplenectomy. Limited pancreatectomies comprised 15 spleen-preserving distal pancreatectomies (42.8%), 10 enucleations (28.6%), and 4 central pancreatectomies (11.4%). Lymph node metastasis was not found in 6 patients who underwent distal pancreatectomy with a splenectomy; meanwhile, the others were regarded as pNx since no lymph node retrieval was attempted during the limited pancreatectomy. Overall disease-free survival was 36.5 months (95% confidence interval [CI]: 25.9-47.1) and no tumor-related mortality was noted. Minimally invasive pancreatectomy (P=0.557) and limited pancreatectomy (P=0.758) showed no adverse impact in treating NF NET-G1 of the left side of the pancreas. The oncologic significance of lymph node metastasis is overestimated in NF NET-G1 of the left side of the pancreas. Routine conventional distal pancreatosplenectomy to retrieve regional lymph nodes may be too excessive in treating NF NET-G1 of the distal pancreas.

Original languageEnglish
Article numbere1404
JournalMedicine (United States)
Volume94
Issue number36
DOIs
Publication statusPublished - 2015 Sep 1

Fingerprint

Pancreatectomy
Neuroendocrine Tumors
Pancreas
Lymph Nodes
Neoplasm Metastasis
Splenectomy
Lymph Node Excision
Disease-Free Survival
Medical Records
Neoplasms
Spleen
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{e7873e8cf6fd4fb28ab1d3a417d187a6,
title = "Overestimated oncologic significance of lymph node metastasis in G1 nonfunctioning neuroendocrine tumor in the left side of the pancreas",
abstract = "Recent studies have expounded on the oncologic significance of lymph node metastasis in nonfunctioning (NF) neuroendocrine tumors (NETs) of the pancreas and suggest regional lymph node dissection for treating pancreatic NET. We tested this recommendation in NF pancreatic NET-G1, as these tumors are generally small and suitable for function-preserving minimally invasive pancreatectomy. From January 2005 to December 2014, medical records of patients who underwent pancreatectomy for pathologically confirmed NF NETG1 of the left side of the pancreas were retrospectively reviewed. Oncologic outcomes were compared between limited pancreatectomy and distal pancreatosplenectomy. Thirty-five patients (14 males and 21 females) with a mean age of 55.9±11.4 years were enrolled in this study. Six patients (17.1{\%}) underwent distal pancreatosplenectomy. Limited pancreatectomies comprised 15 spleen-preserving distal pancreatectomies (42.8{\%}), 10 enucleations (28.6{\%}), and 4 central pancreatectomies (11.4{\%}). Lymph node metastasis was not found in 6 patients who underwent distal pancreatectomy with a splenectomy; meanwhile, the others were regarded as pNx since no lymph node retrieval was attempted during the limited pancreatectomy. Overall disease-free survival was 36.5 months (95{\%} confidence interval [CI]: 25.9-47.1) and no tumor-related mortality was noted. Minimally invasive pancreatectomy (P=0.557) and limited pancreatectomy (P=0.758) showed no adverse impact in treating NF NET-G1 of the left side of the pancreas. The oncologic significance of lymph node metastasis is overestimated in NF NET-G1 of the left side of the pancreas. Routine conventional distal pancreatosplenectomy to retrieve regional lymph nodes may be too excessive in treating NF NET-G1 of the distal pancreas.",
author = "Yoo, {Young Jin} and Yang, {Seok Jeong} and Hwang, {Ho Kyoung} and Kang, {Chang Moo} and Hogeun Kim and Lee, {Woo Jung}",
year = "2015",
month = "9",
day = "1",
doi = "10.1097/MD.0000000000001404",
language = "English",
volume = "94",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "36",

}

Overestimated oncologic significance of lymph node metastasis in G1 nonfunctioning neuroendocrine tumor in the left side of the pancreas. / Yoo, Young Jin; Yang, Seok Jeong; Hwang, Ho Kyoung; Kang, Chang Moo; Kim, Hogeun; Lee, Woo Jung.

In: Medicine (United States), Vol. 94, No. 36, e1404, 01.09.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Overestimated oncologic significance of lymph node metastasis in G1 nonfunctioning neuroendocrine tumor in the left side of the pancreas

AU - Yoo, Young Jin

AU - Yang, Seok Jeong

AU - Hwang, Ho Kyoung

AU - Kang, Chang Moo

AU - Kim, Hogeun

AU - Lee, Woo Jung

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Recent studies have expounded on the oncologic significance of lymph node metastasis in nonfunctioning (NF) neuroendocrine tumors (NETs) of the pancreas and suggest regional lymph node dissection for treating pancreatic NET. We tested this recommendation in NF pancreatic NET-G1, as these tumors are generally small and suitable for function-preserving minimally invasive pancreatectomy. From January 2005 to December 2014, medical records of patients who underwent pancreatectomy for pathologically confirmed NF NETG1 of the left side of the pancreas were retrospectively reviewed. Oncologic outcomes were compared between limited pancreatectomy and distal pancreatosplenectomy. Thirty-five patients (14 males and 21 females) with a mean age of 55.9±11.4 years were enrolled in this study. Six patients (17.1%) underwent distal pancreatosplenectomy. Limited pancreatectomies comprised 15 spleen-preserving distal pancreatectomies (42.8%), 10 enucleations (28.6%), and 4 central pancreatectomies (11.4%). Lymph node metastasis was not found in 6 patients who underwent distal pancreatectomy with a splenectomy; meanwhile, the others were regarded as pNx since no lymph node retrieval was attempted during the limited pancreatectomy. Overall disease-free survival was 36.5 months (95% confidence interval [CI]: 25.9-47.1) and no tumor-related mortality was noted. Minimally invasive pancreatectomy (P=0.557) and limited pancreatectomy (P=0.758) showed no adverse impact in treating NF NET-G1 of the left side of the pancreas. The oncologic significance of lymph node metastasis is overestimated in NF NET-G1 of the left side of the pancreas. Routine conventional distal pancreatosplenectomy to retrieve regional lymph nodes may be too excessive in treating NF NET-G1 of the distal pancreas.

AB - Recent studies have expounded on the oncologic significance of lymph node metastasis in nonfunctioning (NF) neuroendocrine tumors (NETs) of the pancreas and suggest regional lymph node dissection for treating pancreatic NET. We tested this recommendation in NF pancreatic NET-G1, as these tumors are generally small and suitable for function-preserving minimally invasive pancreatectomy. From January 2005 to December 2014, medical records of patients who underwent pancreatectomy for pathologically confirmed NF NETG1 of the left side of the pancreas were retrospectively reviewed. Oncologic outcomes were compared between limited pancreatectomy and distal pancreatosplenectomy. Thirty-five patients (14 males and 21 females) with a mean age of 55.9±11.4 years were enrolled in this study. Six patients (17.1%) underwent distal pancreatosplenectomy. Limited pancreatectomies comprised 15 spleen-preserving distal pancreatectomies (42.8%), 10 enucleations (28.6%), and 4 central pancreatectomies (11.4%). Lymph node metastasis was not found in 6 patients who underwent distal pancreatectomy with a splenectomy; meanwhile, the others were regarded as pNx since no lymph node retrieval was attempted during the limited pancreatectomy. Overall disease-free survival was 36.5 months (95% confidence interval [CI]: 25.9-47.1) and no tumor-related mortality was noted. Minimally invasive pancreatectomy (P=0.557) and limited pancreatectomy (P=0.758) showed no adverse impact in treating NF NET-G1 of the left side of the pancreas. The oncologic significance of lymph node metastasis is overestimated in NF NET-G1 of the left side of the pancreas. Routine conventional distal pancreatosplenectomy to retrieve regional lymph nodes may be too excessive in treating NF NET-G1 of the distal pancreas.

UR - http://www.scopus.com/inward/record.url?scp=84941711284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941711284&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000001404

DO - 10.1097/MD.0000000000001404

M3 - Article

C2 - 26356692

AN - SCOPUS:84941711284

VL - 94

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 36

M1 - e1404

ER -