Overexpression and implications of melanoma-associated antigen a12 in pathogenesis of human cutaneous squamous cell carcinoma

Guohua Zhao, Jung Yoon Bae, Zhenlong Zheng, Hae Seok Park, Kee Yang Chung, Mi Ryung Roh, Zhehu Jin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aim: Melanoma-associated antigen A12 (MAGEA12) has recently been reported as a repressor of tumor-suppressor genes. This study aimed to investigate the implications of MAGEA12 expression in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). Materials and Methods: MAGEA12 and p21 expression were investigated in 15 samples of normal skin and 111 of cSCC tissues by immunohistochemistry. The biological functions of MAGEA12 in cSCC were also investigated both in vitro and in vivo. Results: Expression of both MAGEA12 and p21 was significantly increased in cSCC. MAGEA12 expression showed a positive correlation, while p21 expression showed negative correlation with the recurrence-free survival of patients with cSCC. In addition, MAGEA12 knockdown significantly attenuated proliferative, migratory, invasive, and tumorigenic activities of cSCC cells and was negatively correlated with p21 expression both in vitro and in vivo. Conclusion: MAGEA12-mediated down-regulation of p21 may be involved in cSCC pathogenesis and MAGEA12 may serve as a molecular biomarker in cSCC.

Original languageEnglish
Pages (from-to)1849-1857
Number of pages9
JournalAnticancer research
Volume39
Issue number4
DOIs
Publication statusPublished - 2019 Apr

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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