Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth

Young J. Oh; Barbara C. Swarzenski; Karen L. O'Malley

doi:10.1016/0304-3940(95)12235-4

Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth

Young J. Oh, Barbara C. Swarzenski, Karen L. O'Malley

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Abstract

A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	Neuroscience Letters
Volume	202
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(95)12235-4
Publication status	Published - 1996 Jan 5

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All Science Journal Classification (ASJC) codes

Neuroscience(all)

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Oh, Y. J., Swarzenski, B. C., & O'Malley, K. L. (1996). Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. Neuroscience Letters, 202(3), 161-164. https://doi.org/10.1016/0304-3940(95)12235-4

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10.1016/0304-3940(95)12235-4