Abstract
A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 161-164 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 202 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 Jan 5 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. / Oh, Young Jun; Swarzenski, Barbara C.; O'Malley, Karen L.
In: Neuroscience Letters, Vol. 202, No. 3, 05.01.1996, p. 161-164.Research output: Contribution to journal › Article
TY - JOUR
T1 - Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth
AU - Oh, Young Jun
AU - Swarzenski, Barbara C.
AU - O'Malley, Karen L.
PY - 1996/1/5
Y1 - 1996/1/5
N2 - A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
AB - A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0030071203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030071203&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)12235-4
DO - 10.1016/0304-3940(95)12235-4
M3 - Article
C2 - 8848256
AN - SCOPUS:0030071203
VL - 202
SP - 161
EP - 164
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -