Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth

Young Jun Oh, Barbara C. Swarzenski, Karen L. O'Malley

Research output: Contribution to journalArticle

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Abstract

A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume202
Issue number3
DOIs
Publication statusPublished - 1996 Jan 5

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Synaptosomal-Associated Protein 25
Cell Line
Neurogenesis
Neurites
Cell Division
Neuronal Outgrowth

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Oh, Young Jun ; Swarzenski, Barbara C. ; O'Malley, Karen L. / Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. In: Neuroscience Letters. 1996 ; Vol. 202, No. 3. pp. 161-164.
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Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. / Oh, Young Jun; Swarzenski, Barbara C.; O'Malley, Karen L.

In: Neuroscience Letters, Vol. 202, No. 3, 05.01.1996, p. 161-164.

Research output: Contribution to journalArticle

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