Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain

Hye Ran Lee, Joo Hang Kim, Hyo Dong Uhm, Joong Bae Ahn, Sun Young Rha, Jae Yong Cho, Jong In Lee, Kyong Hee Lee, Hyun Cheol Chung, Jae Kyong Roh, Jin Sik Min, Kyong Sik Lee, Dong Hwan Shin, Byung Soo Kim, Byung Soo Kim, Soon Won Hong, Jin Hyuk Choi

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Abstract

An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalOncology (Switzerland)
Volume53
Issue number3
DOIs
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Lee, H. R., Kim, J. H., Uhm, H. D., Ahn, J. B., Rha, S. Y., Cho, J. Y., Lee, J. I., Lee, K. H., Chung, H. C., Roh, J. K., Min, J. S., Lee, K. S., Shin, D. H., Kim, B. S., Kim, B. S., Hong, S. W., & Choi, J. H. (1996). Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain. Oncology (Switzerland), 53(3), 192-197. https://doi.org/10.1159/000227559