Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain

Hye Ran Lee, Joo Hang Kim, Hyo Dong Uhm, Joong Bae Ahn, SunYoung Rha, Jae Yong Cho, Jong In Lee, Kyong Hee Lee, Hyuncheol Chung, Jae Kyong Roh, Jin Sik Min, Kyong Sik Lee, Dong Hwan Shin, Byung Soo Kim, Byung Soo Kim, Soon Won Hong, Jin Hyuk Choi

Research output: Contribution to journalArticle

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Abstract

An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalOncology (Switzerland)
Volume53
Issue number3
DOIs
Publication statusPublished - 1996 Jan 1

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ErbB-2 Receptor
Stomach Neoplasms
Coloring Agents
Negative Staining
Paraffin
Disease Progression
Stomach
Survival Rate
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis
Carcinoma
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, H. R., Kim, J. H., Uhm, H. D., Ahn, J. B., Rha, S., Cho, J. Y., ... Choi, J. H. (1996). Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain. Oncology (Switzerland), 53(3), 192-197. https://doi.org/10.1159/000227559
Lee, Hye Ran ; Kim, Joo Hang ; Uhm, Hyo Dong ; Ahn, Joong Bae ; Rha, SunYoung ; Cho, Jae Yong ; Lee, Jong In ; Lee, Kyong Hee ; Chung, Hyuncheol ; Roh, Jae Kyong ; Min, Jin Sik ; Lee, Kyong Sik ; Shin, Dong Hwan ; Kim, Byung Soo ; Kim, Byung Soo ; Hong, Soon Won ; Choi, Jin Hyuk. / Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain. In: Oncology (Switzerland). 1996 ; Vol. 53, No. 3. pp. 192-197.
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abstract = "An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4{\%} of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54{\%} in the negative staining group to the c-ErbB-2 protein and 49{\%} in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.",
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Lee, HR, Kim, JH, Uhm, HD, Ahn, JB, Rha, S, Cho, JY, Lee, JI, Lee, KH, Chung, H, Roh, JK, Min, JS, Lee, KS, Shin, DH, Kim, BS, Kim, BS, Hong, SW & Choi, JH 1996, 'Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain', Oncology (Switzerland), vol. 53, no. 3, pp. 192-197. https://doi.org/10.1159/000227559

Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain. / Lee, Hye Ran; Kim, Joo Hang; Uhm, Hyo Dong; Ahn, Joong Bae; Rha, SunYoung; Cho, Jae Yong; Lee, Jong In; Lee, Kyong Hee; Chung, Hyuncheol; Roh, Jae Kyong; Min, Jin Sik; Lee, Kyong Sik; Shin, Dong Hwan; Kim, Byung Soo; Kim, Byung Soo; Hong, Soon Won; Choi, Jin Hyuk.

In: Oncology (Switzerland), Vol. 53, No. 3, 01.01.1996, p. 192-197.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Overexpression of c-erbb-2 protein in gastric cancer by immunohistochemical stain

AU - Lee, Hye Ran

AU - Kim, Joo Hang

AU - Uhm, Hyo Dong

AU - Ahn, Joong Bae

AU - Rha, SunYoung

AU - Cho, Jae Yong

AU - Lee, Jong In

AU - Lee, Kyong Hee

AU - Chung, Hyuncheol

AU - Roh, Jae Kyong

AU - Min, Jin Sik

AU - Lee, Kyong Sik

AU - Shin, Dong Hwan

AU - Kim, Byung Soo

AU - Kim, Byung Soo

AU - Hong, Soon Won

AU - Choi, Jin Hyuk

PY - 1996/1/1

Y1 - 1996/1/1

N2 - An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.

AB - An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.

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