Overexpression of glucose transporter-1 (GLUT-1) predicts poor prognosis in epithelial ovarian cancer

Hanbyoul Cho, You Sun Lee, Julie Kim, Joon Yong Chung, Jae Hoon Kim

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37 Citations (Scopus)


Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p = .029 and p < .001, respectively). On survival analysis, GLUT-1 overexpression (HR = 4.80, p = .027) and lymph node metastases (HR = 8.35, p = .016) conferred a significantly worse overall survival. In conclusion, GLUT-1 expression is remarkably upregulated in EOC and predicts a poor overall survival.

Original languageEnglish
Pages (from-to)607-615
Number of pages9
JournalCancer Investigation
Issue number9
Publication statusPublished - 2013 Nov 1


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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