Overexpression of poliovirus receptor is associated with poor prognosis in head and neck squamous cell carcinoma patients

Sun Min Lim, Min Hee Hong, Sang Jun Ha, Daehee Hwang, Sehyun Chae, Yoon Woo Koh, Eun Chang Choi, Se Heon Kim, Da Hee Kim, Sun Och Yoon, Hye Ryun Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: We aimed to investigate the prognostic value of multiple immune cell markers including programmed death-ligand 1 (PD-L1) and poliovirus receptor (PVR) in head and neck squamous cell carcinoma (HNSCC) using archival tumor tissues Methods: Patients diagnosed with HNSCC who have undergone surgical resection in 2005–2012 were included. Correlations between PVR and PD-L1 expression and patient characteristics were analyzed by analysis of variance. The Kaplan–Meier method and log-rank test were used to estimate survival. P values < 0.05 were considered statistically significant. Results: In total, 375 primary tumor tissues were analyzed using immunohistochemistry. High PVR expression was associated with a poor prognosis in terms of overall survival (OS) and recurrence-free survival (RFS), and tumors with high PVR expression were associated with a short OS. PD-L1 tumor expression did not have a prognostic impact on survival. Univariate analysis revealed that OS and RFS were affected by age and p16 and PVR expression; multivariate analysis revealed that age and p16 and PVR expression were the most important determinants of RFS. Conclusion: PVR overexpression is a poor prognostic factor in patients with HNSCC and co-targeting PVR and PD-L1 may be a promising therapeutic option that needs further investigation.

Original languageEnglish
Pages (from-to)2741-2750
Number of pages10
JournalJournal of cancer research and clinical oncology
Issue number9
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (NRF-2017M3A9E9072669, 2017M3A9E8029717, NRF-2019M3A9B6065231(sc) to H.R.K. and 2018R1A2A1A05076997, 2017R1A5A1014560) and by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (HA16C0015, HA16C0015020019).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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