Overview and introduction to clinical proteomics

Young Ki Paik, Hoguen Kim, Eun Young Lee, Min Seok Kwon, Sang Yun Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

As the field of clinical proteomics progresses, discovery of disease biomarkers becomes paramount. However, the immediate challenges are to establish standard operating procedures for both clinical specimen handling and reduction of sample complexity and to increase the ability to detect proteins and peptides present in low amounts. The traditional concept of a disease biomarker is shining toward a new paradigm, namely, that an ensemble of proteins or peptides would be more efficient than a single protein/peptide in the diagnosis of disease. Because clinical proteomics usually requires easy access to well-defined fresh clinical specimens (including morphologically consistent tissue and properly pretreated body fluids of sufficient, quantity), biorepository systems need to be established. Here, we address these questions and emphasize the necessity of developing various microdissection techniques for tissue specimens, multidimensional fractionation for body fluids, and other related techniques (including bioinformatics), tools which could become integral parts of clinical proteomics for disease biomarker discovery.

Original languageEnglish
Title of host publicationClinical Proteomics - Methods and Protocols
Pages1-31
Number of pages31
Publication statusPublished - 2007 Aug 31

Publication series

NameMethods in Molecular Biology
Volume428
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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    Paik, Y. K., Kim, H., Lee, E. Y., Kwon, M. S., & Cho, S. Y. (2007). Overview and introduction to clinical proteomics. In Clinical Proteomics - Methods and Protocols (pp. 1-31). (Methods in Molecular Biology; Vol. 428).