Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study

Bo Yi Yang; Zhengmin Min Qian; Michael G. Vaughn; Steven W. Howard; John Phillip Pemberton; Huimin Ma; Duo Hong Chen; Li Wen Hu; Xiao Wen Zeng; Chuan Zhang; Yan Peng Tian; Min Nian; Xiang Xiao; Guang Hui Dong

doi:10.1186/s12940-018-0401-2

Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study

Bo Yi Yang, Zhengmin Min Qian, Michael G. Vaughn, Steven W. Howard, John Phillip Pemberton, Huimin Ma, Duo Hong Chen, Li Wen Hu, Xiao Wen Zeng, Chuan Zhang, Yan Peng Tian, Min Nian, Xiang Xiao, Guang Hui Dong

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. Methods: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM₁₀), sulfur dioxides (SO₂), nitrogen dioxides (NO₂), and ozone (O₃) were calculated at monitoring stations. Generalized additive models and 2-level regression analyses were applied. Results: We observed significant interactions between air pollutants and overweight on prehypertension and blood pressure. The associations of PM₁₀, SO₂, NO₂, and O₃ with prehypertension were significant among overweight participants (Prevalence Rate Ratios (PRRs) per interquartile range (IQR) of air pollutants: 1.14-1.20), but not among normal weight participants (PRRs: 0.98-1.04). PM₁₀, SO₂, and O₃ were significantly associated with systolic blood pressure (SBP), and the magnitudes of these associations were higher among overweight adults (increases in SBP per IQR of air pollutants: 1.82-4.53 mmHg) than those among normal weight adults (increases in SBP: 0.42-0.61 mmHg). For diastolic blood pressure (DBP), significant associations were mainly observed in overweight participants (increases in DBP: 0.80-1.63 mmHg). Further stratified analyses showed that all these interactions were stronger in women, the older, and participants living in areas with lower income levels or higher population density. Conclusions: Being overweight may enhance the effects of ambient air pollution on prehypertension and blood pressure in Chinese adults.

Original language	English
Article number	57
Journal	Environmental Health: A Global Access Science Source
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12940-018-0401-2
Publication status	Published - 2018 Jun 28

Bibliographical note

Funding Information:
The research was funded by the National Natural Science Foundation of China (No.91543208; No.81703179; No.81673128); the National Key Research and Development Program of China (No.2016YFC0207000); the Fundamental Research Funds for the Central Universities (No.16ykzd02; No.17ykpy16); the Guangdong Province Natural Science Foundation (No.2016A030313342; 2017A050501062); and Science and Technology Program of Guangzhou (201807010032; 201803010054). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication.

Publisher Copyright:
© 2018 The Author(s).

All Science Journal Classification (ASJC) codes

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1186/s12940-018-0401-2

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Yang, B. Y., Qian, Z. M., Vaughn, M. G., Howard, S. W., Pemberton, J. P., Ma, H., Chen, D. H., Hu, L. W., Zeng, X. W., Zhang, C., Tian, Y. P., Nian, M., Xiao, X., & Dong, G. H. (2018). Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study. Environmental Health: A Global Access Science Source, 17(1), [57]. https://doi.org/10.1186/s12940-018-0401-2

Yang, Bo Yi ; Qian, Zhengmin Min ; Vaughn, Michael G. ; Howard, Steven W. ; Pemberton, John Phillip ; Ma, Huimin ; Chen, Duo Hong ; Hu, Li Wen ; Zeng, Xiao Wen ; Zhang, Chuan ; Tian, Yan Peng ; Nian, Min ; Xiao, Xiang ; Dong, Guang Hui. / Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults : The 33 Communities Chinese Health Study. In: Environmental Health: A Global Access Science Source. 2018 ; Vol. 17, No. 1.

@article{298b18e1533f420487944e33ce0d60c3,

title = "Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study",

abstract = "Background: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. Methods: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM10), sulfur dioxides (SO2), nitrogen dioxides (NO2), and ozone (O3) were calculated at monitoring stations. Generalized additive models and 2-level regression analyses were applied. Results: We observed significant interactions between air pollutants and overweight on prehypertension and blood pressure. The associations of PM10, SO2, NO2, and O3 with prehypertension were significant among overweight participants (Prevalence Rate Ratios (PRRs) per interquartile range (IQR) of air pollutants: 1.14-1.20), but not among normal weight participants (PRRs: 0.98-1.04). PM10, SO2, and O3 were significantly associated with systolic blood pressure (SBP), and the magnitudes of these associations were higher among overweight adults (increases in SBP per IQR of air pollutants: 1.82-4.53 mmHg) than those among normal weight adults (increases in SBP: 0.42-0.61 mmHg). For diastolic blood pressure (DBP), significant associations were mainly observed in overweight participants (increases in DBP: 0.80-1.63 mmHg). Further stratified analyses showed that all these interactions were stronger in women, the older, and participants living in areas with lower income levels or higher population density. Conclusions: Being overweight may enhance the effects of ambient air pollution on prehypertension and blood pressure in Chinese adults.",

author = "Yang, {Bo Yi} and Qian, {Zhengmin Min} and Vaughn, {Michael G.} and Howard, {Steven W.} and Pemberton, {John Phillip} and Huimin Ma and Chen, {Duo Hong} and Hu, {Li Wen} and Zeng, {Xiao Wen} and Chuan Zhang and Tian, {Yan Peng} and Min Nian and Xiang Xiao and Dong, {Guang Hui}",

note = "Funding Information: The research was funded by the National Natural Science Foundation of China (No.91543208; No.81703179; No.81673128); the National Key Research and Development Program of China (No.2016YFC0207000); the Fundamental Research Funds for the Central Universities (No.16ykzd02; No.17ykpy16); the Guangdong Province Natural Science Foundation (No.2016A030313342; 2017A050501062); and Science and Technology Program of Guangzhou (201807010032; 201803010054). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication. Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = jun,

day = "28",

doi = "10.1186/s12940-018-0401-2",

language = "English",

volume = "17",

journal = "Environmental Health: A Global Access Science Source",

issn = "1476-069X",

publisher = "BioMed Central",

number = "1",

}

Yang, BY, Qian, ZM, Vaughn, MG, Howard, SW, Pemberton, JP, Ma, H, Chen, DH, Hu, LW, Zeng, XW, Zhang, C, Tian, YP, Nian, M, Xiao, X & Dong, GH 2018, 'Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study', Environmental Health: A Global Access Science Source, vol. 17, no. 1, 57. https://doi.org/10.1186/s12940-018-0401-2

Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults : The 33 Communities Chinese Health Study. / Yang, Bo Yi; Qian, Zhengmin Min; Vaughn, Michael G.; Howard, Steven W.; Pemberton, John Phillip; Ma, Huimin; Chen, Duo Hong; Hu, Li Wen; Zeng, Xiao Wen; Zhang, Chuan; Tian, Yan Peng; Nian, Min; Xiao, Xiang; Dong, Guang Hui.

In: Environmental Health: A Global Access Science Source, Vol. 17, No. 1, 57, 28.06.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults

T2 - The 33 Communities Chinese Health Study

AU - Yang, Bo Yi

AU - Qian, Zhengmin Min

AU - Vaughn, Michael G.

AU - Howard, Steven W.

AU - Pemberton, John Phillip

AU - Ma, Huimin

AU - Chen, Duo Hong

AU - Hu, Li Wen

AU - Zeng, Xiao Wen

AU - Zhang, Chuan

AU - Tian, Yan Peng

AU - Nian, Min

AU - Xiao, Xiang

AU - Dong, Guang Hui

N1 - Funding Information: The research was funded by the National Natural Science Foundation of China (No.91543208; No.81703179; No.81673128); the National Key Research and Development Program of China (No.2016YFC0207000); the Fundamental Research Funds for the Central Universities (No.16ykzd02; No.17ykpy16); the Guangdong Province Natural Science Foundation (No.2016A030313342; 2017A050501062); and Science and Technology Program of Guangzhou (201807010032; 201803010054). The views stated within this article are those of the authors and do not necessarily describe the views of the funding source. The funding source did not have control of the design or analysis of the study publication. Publisher Copyright: © 2018 The Author(s).

PY - 2018/6/28

Y1 - 2018/6/28

N2 - Background: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. Methods: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM10), sulfur dioxides (SO2), nitrogen dioxides (NO2), and ozone (O3) were calculated at monitoring stations. Generalized additive models and 2-level regression analyses were applied. Results: We observed significant interactions between air pollutants and overweight on prehypertension and blood pressure. The associations of PM10, SO2, NO2, and O3 with prehypertension were significant among overweight participants (Prevalence Rate Ratios (PRRs) per interquartile range (IQR) of air pollutants: 1.14-1.20), but not among normal weight participants (PRRs: 0.98-1.04). PM10, SO2, and O3 were significantly associated with systolic blood pressure (SBP), and the magnitudes of these associations were higher among overweight adults (increases in SBP per IQR of air pollutants: 1.82-4.53 mmHg) than those among normal weight adults (increases in SBP: 0.42-0.61 mmHg). For diastolic blood pressure (DBP), significant associations were mainly observed in overweight participants (increases in DBP: 0.80-1.63 mmHg). Further stratified analyses showed that all these interactions were stronger in women, the older, and participants living in areas with lower income levels or higher population density. Conclusions: Being overweight may enhance the effects of ambient air pollution on prehypertension and blood pressure in Chinese adults.

AB - Background: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. Methods: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM10), sulfur dioxides (SO2), nitrogen dioxides (NO2), and ozone (O3) were calculated at monitoring stations. Generalized additive models and 2-level regression analyses were applied. Results: We observed significant interactions between air pollutants and overweight on prehypertension and blood pressure. The associations of PM10, SO2, NO2, and O3 with prehypertension were significant among overweight participants (Prevalence Rate Ratios (PRRs) per interquartile range (IQR) of air pollutants: 1.14-1.20), but not among normal weight participants (PRRs: 0.98-1.04). PM10, SO2, and O3 were significantly associated with systolic blood pressure (SBP), and the magnitudes of these associations were higher among overweight adults (increases in SBP per IQR of air pollutants: 1.82-4.53 mmHg) than those among normal weight adults (increases in SBP: 0.42-0.61 mmHg). For diastolic blood pressure (DBP), significant associations were mainly observed in overweight participants (increases in DBP: 0.80-1.63 mmHg). Further stratified analyses showed that all these interactions were stronger in women, the older, and participants living in areas with lower income levels or higher population density. Conclusions: Being overweight may enhance the effects of ambient air pollution on prehypertension and blood pressure in Chinese adults.

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UR - http://www.scopus.com/inward/citedby.url?scp=85049159203&partnerID=8YFLogxK

U2 - 10.1186/s12940-018-0401-2

DO - 10.1186/s12940-018-0401-2

M3 - Article

C2 - 29954383

AN - SCOPUS:85049159203

VL - 17

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

M1 - 57

ER -

Overweight modifies the association between long-term ambient air pollution and prehypertension in Chinese adults: The 33 Communities Chinese Health Study

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