Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period

Hye In Kim, Inha Lee, Sang Hwa Kim, Yong Seung Lee, Sang Won Han, Bo Hyon Yun

Research output: Contribution to journalArticlepeer-review

Abstract

Study objective: To present clinical features that characterize ovotesticular disorder of sex development (OT-DSD) in the Korean population. Among the patient cohort who were initially suspected to have OT-DSD, the actual OT-DSD patients and those of other disorder of sex development were compared. Design: Retrospective medical chart review of patients who were initially suspected to have OT-DSD from 1984 to 2018 on the basis of clinical examination. Setting: Tertiary care university hospital. Participants: Of 26 patients with initial diagnosis of OT-DSD, 3 were excluded because of incomplete records, and finally, 23 patients were subjected to analysis. Various examinations were performed before the surgical confirmation of gonad histopathology. Interventions: Medical records were reviewed for clinical, anatomical, biochemical, and cytogenic characteristics, gender assignment, medical treatment, and histopathologic diagnosis. Main Outcome Measures: Characteristics of OT-DSD in a Korean population. Results: Among 23 patients suspected to have OT-DSD, 13/23 (56.5%) were diagnosed as OT-DSD after histopathologic confirmation. Of the remaining 10 patients, 5/23 (21.7%) were diagnosed with mixed gonadal dysgenesis, 3 with Turner variant, 1 with 46,XX disorder of sex development, and 1 with Mayer-Rokitansky-Küster-Hauser syndrome. Among the 13 OT-DSD cases, 9 patients presented with the 46,XX karyotype, 1 with the 46,XY, and 3 with the 46,XX/XY karyotype. Nine patients were assigned as male and 4 as female at birth. The most common gonad histology was ovotestis 10/26 (38%), followed by ovary and testis. Conclusion: OT-DSD is one of the rarest disorders with various clinical presentations. A patient with ambiguous genitalia must be examined with a multidisciplinary approach with clinical suspicion for OT-DSD. Standardized procedure of evaluation and treatment is crucial.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalJournal of Pediatric and Adolescent Gynecology
Volume34
Issue number5
DOIs
Publication statusAccepted/In press - 2021

Bibliographical note

Funding Information:
The authors thank the members of the Department of Obstetrics and Gynecology, Yonsei University College of Medicine, for their generous support of this research.

Publisher Copyright:
© 2021 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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