Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

Jee Eun Lee, Sharif Md Abuzar, Yeji Seo, Hyeji Han, Youngbae Jeon, Eun Jung Park, Seung Hyuk Baik, Sung Joo Hwang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer among both men and women worldwide. New therapeutic strategies involving cytoreductive surgery and intra-peritoneal chemotherapy could lead to a definitive cure in some cases. However, postoperative intra-abdominal adhesion can cause further complications. In this study, hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based novel cross-linked hydrogels (HC hydrogels) were synthesized and fully characterized. We demonstrated that varied compositions of HA and CMCNa altered the microstructure, rheology, and degradation behavior of hydrogels. Pre-constructed hydrogels were further loaded with oxaliplatin to prevent intra-abdominal adhesion following chemotherapy. Sustained release of oxaliplatin was observed from hydrogels compared that from solutions, which release drugs through diffusion, following the Higuchi and Korsmeyer-Peppas models. Moreover, low adhesion scores in an in vivo SD rat model demonstrated inhibition of intra-peritoneal adhesion in response to HC hydrogels. Therefore, HC hydrogels offer a novel formulation strategy for providing an intra-abdominal anti-adhesion barrier after cytoreductive surgery and intra-peritoneal chemotherapy for CRC treatment.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume565
DOIs
Publication statusPublished - 2019 Jun 30

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oxaliplatin
Hydrogels
Colorectal Neoplasms
Hyaluronic Acid
Drug Therapy
Therapeutics
Carboxymethylcellulose Sodium
Rheology

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Lee, Jee Eun ; Abuzar, Sharif Md ; Seo, Yeji ; Han, Hyeji ; Jeon, Youngbae ; Park, Eun Jung ; Baik, Seung Hyuk ; Hwang, Sung Joo. / Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy. In: International Journal of Pharmaceutics. 2019 ; Vol. 565. pp. 50-58.
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Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy. / Lee, Jee Eun; Abuzar, Sharif Md; Seo, Yeji; Han, Hyeji; Jeon, Youngbae; Park, Eun Jung; Baik, Seung Hyuk; Hwang, Sung Joo.

In: International Journal of Pharmaceutics, Vol. 565, 30.06.2019, p. 50-58.

Research output: Contribution to journalArticle

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AU - Lee, Jee Eun

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AU - Jeon, Youngbae

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AU - Hwang, Sung Joo

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