Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

Jee Eun Lee, Sharif Md Abuzar, Yeji Seo, Hyeji Han, Youngbae Jeon, Eun Jung Park, Seung Hyuk Baik, Sung Joo Hwang

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Colorectal cancer (CRC) is the third most commonly diagnosed cancer among both men and women worldwide. New therapeutic strategies involving cytoreductive surgery and intra-peritoneal chemotherapy could lead to a definitive cure in some cases. However, postoperative intra-abdominal adhesion can cause further complications. In this study, hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based novel cross-linked hydrogels (HC hydrogels) were synthesized and fully characterized. We demonstrated that varied compositions of HA and CMCNa altered the microstructure, rheology, and degradation behavior of hydrogels. Pre-constructed hydrogels were further loaded with oxaliplatin to prevent intra-abdominal adhesion following chemotherapy. Sustained release of oxaliplatin was observed from hydrogels compared that from solutions, which release drugs through diffusion, following the Higuchi and Korsmeyer-Peppas models. Moreover, low adhesion scores in an in vivo SD rat model demonstrated inhibition of intra-peritoneal adhesion in response to HC hydrogels. Therefore, HC hydrogels offer a novel formulation strategy for providing an intra-abdominal anti-adhesion barrier after cytoreductive surgery and intra-peritoneal chemotherapy for CRC treatment.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalInternational Journal of Pharmaceutics
Publication statusPublished - 2019 Jun 30

Bibliographical note

Funding Information:
This study was supported by a grant from the Faculty Research Grant of Yonsei University College of Medicine for 2017(6-2017-0091) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT & Future Planning, Republic of Korea (NRF-2017R1A2B2011520, NRF-2017R1D1A1B03031213, and University-Centered Labs-2018R1A6A1A03023718).

Publisher Copyright:
© 2019 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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