Oxidation of DNA bases is influenced by their position in the DNA strand

Rou Jun Toh, Alessandra Bonanni, Martin Pumera

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Electrochemical detection of DNA is an important field of research, with strong implications for next generation diagnostics. In this paper, we show that the electrochemical responses of DNA bases (guanine, adenine, thymine, cytosine) in terms of peak potentials and peak current may be influenced by the sequences of an oligomer at standard glassy carbon (GC), as well as electrochemically reduced graphene oxide electrode. We have observed that the effects were more significant on the oxidative peaks of adenine and thymine on the GC-electrode. Deviations in peak potentials were generally low. Our findings are principally important for fundamental studies and future developments in DNA detection and analysis.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalElectrochemistry Communications
Volume22
Issue number1
DOIs
Publication statusPublished - 2012 Aug 1

All Science Journal Classification (ASJC) codes

  • Electrochemistry

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