Oxidative stress and chronic allograft nephropathy

Hunjoo Ha, Jehyun Park, Yu Seun Kim, Hitoshi Endou

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Oxidative stress defined as outbalanced generation of reactive oxygen species (ROS) than the existing antioxidative defense mechanisms plays an important role in tissue injury. Ischemia/reperfusion accompanied during organ transplantation is well- established oxidative stress-induced tissue injury. We hypothesized that oxidative stress may also play a role in the development and progression of chronic allograft nephropathy (CAN), since that ROS are major signaling molecules of growth factors and cytokines [platelet-derived growth factors, transforming growth factor-β1 (TGF-β1)] upregulated in the Kidney of CAN, that ROS in turn upregulate TGF-β1, and that myeophenolic acid may inhibit features of CAN [proliferation and extracellular matrix (ECM) accumulation in vascular smooth muscle cells and glomerular mesangial cells] through inhibiting cellular ROS. Cellular ROS activate signal transduction cascade (protein kinase C, mitogen-activated protein kinases, and janus kinases) and transcription factors (nuclear factor-κB, activated protein-1, specificity protein 1, and signal transducers and activators of transcription) leading to regulation of genes and proteins involved in cellular proliferation, ECM remodeling, and apoptosis accompanied in CAN. This review is intended to provide an overview of oxidative stress in renal allograft nephropathy.

Original languageEnglish
Pages (from-to)1049-1052
Number of pages4
JournalYonsei medical journal
Volume45
Issue number6
DOIs
Publication statusPublished - 2004 Dec 31

Fingerprint

Allografts
Reactive Oxygen Species
Oxidative Stress
Transforming Growth Factors
Extracellular Matrix
STAT Transcription Factors
STAT1 Transcription Factor
Janus Kinases
MAP Kinase Kinase Kinases
Kidney
Mesangial Cells
Platelet-Derived Growth Factor
Wounds and Injuries
Organ Transplantation
Vascular Smooth Muscle
Protein Kinase C
Reperfusion
Smooth Muscle Myocytes
Signal Transduction
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ha, Hunjoo ; Park, Jehyun ; Kim, Yu Seun ; Endou, Hitoshi. / Oxidative stress and chronic allograft nephropathy. In: Yonsei medical journal. 2004 ; Vol. 45, No. 6. pp. 1049-1052.
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Oxidative stress and chronic allograft nephropathy. / Ha, Hunjoo; Park, Jehyun; Kim, Yu Seun; Endou, Hitoshi.

In: Yonsei medical journal, Vol. 45, No. 6, 31.12.2004, p. 1049-1052.

Research output: Contribution to journalReview article

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